Effects of Endoscopic Sinus Surgery Combined with Budesonide Treatment on Nasal Cavity Function and Serum Inflammatory Factors in Patients with Chronic Sinusitis

Abstract

In this article, we have explored the effects of endoscopic sinus surgery together with budesonide treatment on nasal function and serum inflammatory factors on patients with chronic sinusitis. We retrospectively analyzed 120 patients with chronic sinusitis who were admitted to our hospital from March 2018 to March 2021 and were eligible for this study. They were separated into 2 groups according to different treatments, that is, the control group (treated with endoscopic surgery alone) of 58 cases and observation group (treated with endoscopic sinus surgery combined with budesonide) with 62 cases. Treatment efficacy, surgical status, overall symptom score before and after treatment, nasal mucociliary clearance function, serum eosinophils (EOS), serum immunoglobulin E (IgE), serum inflammatory factors, and occurrence of adverse reactions of both groups were recorded and compared. Total effective rate in the observation group presented strikingly more positive compared with that among patients in control group (P<0.05), as well as the data recorded in terms of operation time, blood loss during surgery and postoperative improvement time of patients (P<0.05). Overall symptom score, nasal mucociliary clearance, EOS, IgE and serum inflammatory factors in both groups were improved notably after treatment, while the observation group held a more obvious improvement. And it also had a markedly lower incidence of adverse reaction (P<0.05). Endoscopic sinus surgery combined with budesonide in the treatment of chronic sinusitis could effectively improve the clinical symptoms of patients, reestablish the function of the nasal cavity and improve their inflammation level. Meanwhile, it was of high safety and is worthy of clinical promotion.

Figure 1

Comparison of nasal mucociliary clearance before and after treatment between two groups of patients; (a) comparison of mucociliary clearance of two groups before and after treatment; (b) comparison of saccharin clearance time between two groups of patients before and after treatment; (c) comparison of mucociliary clearance rate in two groups of patients before and after treatment.^∗P<0.05.

Figure 2

Comparison of serum EOS and Ige between two groups of patients before and after surgery; (a) comparison of serum EOS and IgE between two groups of patients before and after treatment; (b) comparison of serum IgE between two groups of patients before and after treatment. ^∗P<0.05.

Figure 3

Comparison of serum inflammatory factors before and after operation of two groups; (a) comparison of the serum IL-6 of two groups before and after the operation; (b) comparison of serum IL-8 of two groups before and after the operation; (c) comparison of serum TNF-αbetween two groups of patients before and after surgery.^∗P<0.05.