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Review
. 2021 Sep 24:2:722820.
doi: 10.3389/fpain.2021.722820. eCollection 2021.

Biased Opioid Ligands: Revolution or Evolution?

Florence Noble  1 , Nicolas Marie  1
Affiliations
Review

Biased Opioid Ligands: Revolution or Evolution?

Florence Noble et al. Front Pain Res (Lausanne). .

Abstract

Opioid are the most powerful analgesics ever but their use is still limited by deleterious side effects such as tolerance, dependence, and respiratory depression that could eventually lead to a fatal overdose. The opioid crisis, mainly occurring in north America, stimulates research on finding new opioid ligands with reduced side effects. Among them, biased ligands are likely the most promising compounds. We will review some of the latest discovered biased opioid ligands and see if they were able to fulfill these expectations.

Keywords: PZM21; TRV130; analgesia; biased ligands; opioids; side effects.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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