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. 2022 Jun 1:356:73-78.
doi: 10.1016/j.ijcard.2022.03.021. Epub 2022 Mar 13.

Clinical characteristics and 30-day outcomes in patients with acute decompensated heart failure: Results from Indian College of Cardiology National Heart Failure Registry (ICCNHFR)

P B Jayagopal  1 , Sridhar L Sastry  2 , Veena Nanjappa  3 , Jabir Abdullakutty  4 , Johny Joseph  5 , P R Vaidyanathan  6 , Nitin Kabra  7 , P Manokar  8 , Soma Sekhar Ghanta  9 , Vinod Sharma  10 , Trinath Kumar Mishra  11 , Narendra Jathappa  12 , Vikas Singh  13 , S N Routray  14 , Subroto Mandal  15 , Neeraj Bhalla  16 , Prabhakar Dorairaj  17 , Nihar Mehta  18 , Dayanand Kumbla  19 , Abhijit Ramdas Rane  20 , Tapan Kumar Matia  21 , Dharmendra Jain  22 , Gautam Rege  23 , Sunil Modi  24 , V K Chopra  25 , P P Mohanan  26 , A Geevar Zachariah  27 , K S Ravindranath  2 , Rabin Chakraborty  28 , B C Srinivas  2 , T R Raghu  29 , C N Manjunath  2
Affiliations

Clinical characteristics and 30-day outcomes in patients with acute decompensated heart failure: Results from Indian College of Cardiology National Heart Failure Registry (ICCNHFR)

P B Jayagopal et al. Int J Cardiol. .

Abstract

Background: Acute decompensated heart failure (ADHF) is a challenging medical emergency with high mortality and its prevalence is increasing in India. There is paucity of data on ADHF in the country.

Methods: Indian College of Cardiology National Heart Failure Registry (ICCNHFR) is an on-going observational registry on ADHF contributed by 22 hospitals across India; and we present the in-hospital and 30-day outcomes of ADHF patients enrolled from August 2018 to July 2019. Major objective included capturing demographics, comorbid conditions, aetiology, prescription patterns and assessing clinical outcomes.

Results: Of 5269 patients (mean age: 61.90 ± 13.85 years) enrolled in this study, males were predominant (67.09%). Mean duration of hospitalization was 5.74 ± 4.74 days. Ischemic heart disease was the most common (75.44%) aetiology. Abnormal electrocardiogram readings were found in most patients (89.86%). LVEF of ˂40% was found in 68.29% of patients. In-hospital mortality rates were 6.98%. The 30-day cumulative mortality was 12.35% and 30-day rehospitalization rate was 7.98%. At discharge, all guideline-based medical therapy (GDMT) were prescribed only to 24.99% of patients and 23.72% adhered to the prescription until 30 days. Older age, high serum creatinine levels and poor LVEF contributed to high mortality and rehospitalization.

Conclusion: Patients with ADHF were younger and predominantly males. Usage of GDMT in ADHF patients was low (24.99%) and the in-hospital mortality was high. Older age, high serum creatinine levels, poor LVEF contributed for 30-day mortality and rehospitalization. This data on ADHF, could help in developing strategies to improve outcomes for HF patients in India.

Keywords: Acute decompensated heart failure; Heart failure; Indian College of Cardiology National Heart Failure Registry; Left ventricular ejection fraction; Medication patterns; Mortality rates.

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