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Case Reports
. 2022 Jun;47(6):1204-1206.
doi: 10.1111/ced.15131. Epub 2022 Mar 17.

A flexural exanthem following postexposure prophylaxis

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Case Reports

A flexural exanthem following postexposure prophylaxis

Darren Roche et al. Clin Exp Dermatol. 2022 Jun.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Clin Exp Dermatol. 2022 Dec;47(12):2350. doi: 10.1111/ced.15401. Clin Exp Dermatol. 2022. PMID: 36440612 Free PMC article. No abstract available.

Abstract

We report a case of symmetrical drug-related intertriginous and flexural exanthema following antiretroviral postexposure prophylactic medications, tenofovir and emtricitabine, commencement of which preceded the onset of the rash. Tenofovir and emtricitabine are both nucleoside reverse transcriptase inhibitor medications, commonly used to prevent development of AIDS.

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Figures

Figure 1
Figure 1
(a,b) Erythematous rash on (a) the legs and (b) feet.
Figure 2
Figure 2
(a,b) Superficial perivascular and interstitial mixed inflammatory infiltrate, composed of lymphocytes, neutrophils and eosinophils. Haematoxylin and eosin, original magnification (a) × 10; (b) × 40.

References

    1. Häusermann P, Harr T, Bircher AJ. Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Contact Dermatitis 2004; 51: 297–310. - PubMed
    1. Winnicki M, Shear NH. A systematic approach to systemic contact dermatitis and symmetric drug‐related intertriginous and flexural exanthema (SDRIFE): a closer look at these conditions and an approach to intertriginous eruptions. Am J Clin Dermatol 2011; 12: 171–80. - PubMed
    1. Akkari H, Belhadjali H, Youssef M et al. Baboon syndrome induced by hydroxyzine. Indian J Dermatol 2013; 58: 244. - PMC - PubMed
    1. Blackmur JP, Lammy S, Baring DEC. Baboon syndrome: an unusual complication arising from antibiotic treatment of tonsillitis and review of the literature. Case Rep 2013; 2013: bcr2013201977. - PMC - PubMed
    1. Nespoulous L, Matei I, Charissoux A et al. Symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) associated with pristinamycin, secnidazole, and nefopam, with a review of the literature. Contact Dermatitis 2018; 79: 378–80. - PubMed

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