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Editorial
. 2022 Mar 18;130(6):868-870.
doi: 10.1161/CIRCRESAHA.122.320880. Epub 2022 Mar 17.

Sugar, Fat, and YAP: A Recipe for Vascular Stiffness

Arya Mani  1   2 , John Hwa  1 , Kathleen A Martin  1   3
Affiliations
Editorial

Sugar, Fat, and YAP: A Recipe for Vascular Stiffness

Arya Mani et al. Circ Res. .
No abstract available

Keywords: Editorials; YAP-signaling proteins; fat; fibrosis; metabolic syndrome; sugar; transforming growth factor.

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Figures

Figure:
Figure:
Schematic of arterial stiffness induced by HF/HS diet. HF/HS diet increases the activation of mTORC1, suppressing autophagy-induced degradation of YAP in SMC. Increased YAP levels inhibit TGF-β-dependent PPM1B ubiquitination and translocation to the nucleus. Nuclear PPM1B dephosphorylates SMAD2/3, terminating TGF-β signaling. The HF/HS-induced cascade of events results in amplified TGF-β signaling, increasing extracellular matrix protein deposition and arterial stiffness.
See this image and copyright information in PMC

Comment on

References

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