Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Mar 16;110(6):905-907.
doi: 10.1016/j.neuron.2022.02.018.

Advancing discovery of risk-altering variants for complex diseases by functionally informed fine-mapping

You Chen  1 , Andrew G Clark  2 , Haiyuan Yu  3
Affiliations
Free article
Comment

Advancing discovery of risk-altering variants for complex diseases by functionally informed fine-mapping

You Chen et al. Neuron. .
Free article

Abstract

Pinpointing causal variants at risk loci identified by genome-wide association studies (GWAS) has been a great challenge. In this issue of Neuron, Zhang et al. present a fine-mapping approach, RefMap, integrating functional genomics with GWAS summary statistics to prioritize causal variants for amyotrophic lateral sclerosis.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis.
    Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Marshall JNG, Harvey C, Nezhad HG, Franklin J, Souza CDS, Ning K, Wang C, Li J, Dilliott AA, Farhan S, Elhaik E, Pasniceanu I, Livesey MR, Eitan C, Hornstein E, Kenna KP; Project MinE ALS Sequencing Consortium; Veldink JH, Ferraiuolo L, Shaw PJ, Snyder MP. Zhang S, et al. Neuron. 2022 Mar 16;110(6):992-1008.e11. doi: 10.1016/j.neuron.2021.12.019. Epub 2022 Jan 18. Neuron. 2022. PMID: 35045337 Free PMC article.

Publication types

LinkOut - more resources