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Review
. 2022 Mar 1:10:841583.
doi: 10.3389/fbioe.2022.841583. eCollection 2022.

Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

Jianghui Qin  1 , Fang Chen  2 , Pingli Wu  1 , Guoming Sun  2
Affiliations
Review

Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

Jianghui Qin et al. Front Bioeng Biotechnol. .

Abstract

Wound healing is an evolved dynamic biological process. Though many research and clinical approaches have been explored to restore damaged or diseased skin, the current treatment for deep cutaneous injuries is far from being perfect, and the ideal regenerative therapy remains a significant challenge. Of all treatments, bioengineered scaffolds play a key role and represent great progress in wound repair and skin regeneration. In this review, we focus on the latest advancement in biomaterial scaffolds for wound healing. We discuss the emerging philosophy of designing biomaterial scaffolds, followed by precursor development. We pay particular attention to the therapeutic interventions of bioengineered scaffolds for cutaneous wound healing, and their dual effects while conjugating with bioactive molecules, stem cells, and even immunomodulation. As we review the advancement and the challenges of the current strategies, we also discuss the prospects of scaffold development for wound healing.

Keywords: bioengineered scaffolds; biomaterials; pro-regenerative; skin; wound healing.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

GRAPHICAL ABSTRACT
GRAPHICAL ABSTRACT
FIGURE 1
FIGURE 1
Cutaneous wound healing treated with tissue-engineered scaffolds. The wounds are currently treated either with typical biological scaffolds or pro-regenerative ones. Though both scaffolds facilitate wound healing, the pro-regenerative scaffolds bring about more complete skin structures, while the traditional biological scaffolds mostly lead to scarred skin.
FIGURE 2
FIGURE 2
Immuno-engineering pro-regenerative scaffolds for wound healing. (A) Either chemically modifying precursors or regulating the physical structures enable the immunomodulatory properties of the scaffolds. (B) Constructing innate immunomodulatory biomaterials into pro-regenerative scaffolds for skin regeneration. (C) Incorporating immunomodulatory biomolecules into scaffolds to empower the regenerative capacities for wound healing.
FIGURE 3
FIGURE 3
Encapsulating stem cells into scaffolds to enhance wound healing either through contributing to new tissue formation or by releasing regulating biomolecules.
See this image and copyright information in PMC

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