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. 2022 Feb;22(1):149-151.
doi: 10.18295/squmj.5.2021.080. Epub 2022 Feb 28.

Metronidazole Induced Neurotoxicity: A clinico-radiological diagnosis

Amlan K Datta  1 , Uddalak Chakraborty  1 , Adreesh Mukherjee  1 , Arpan Dutta  1 , Sudeshna Malakar  2 , Atanu Chandra  3
Affiliations

Metronidazole Induced Neurotoxicity: A clinico-radiological diagnosis

Amlan K Datta et al. Sultan Qaboos Univ Med J. 2022 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Magnetic resonance imaging scans of the brain of a 44-year-old male patient showing (A) the splenium of corpus callosum with evidence of diffusion restriction (arrow) and (B) hyperintensity (arrow) on fluid attenuation inversion recovery scans. Scans also showed (C) symmetrical areas of hyperintensity involving bilateral lentiform nucleus (arrow) and (D) dentate nucleus of cerebellum (arrow).
Figure 2
Figure 2
Magnetic resonance imaging scans of the brain of a 44-year-old male patient showing (A) axial diffusion weighted image with no restriction in splenium of corpus callosum and (B) axial T2 fluid attenuation inversion recovery sequence showing resolution of hyperintensities in dentate nucleus of cerebellum.
See this image and copyright information in PMC

References

    1. Hernández Ceruelos A, Romero-Quezada LC, Ruvalcaba-Ledezma JC, López Contreras L. Therapeutic uses of metronidazole and its side effects: An update. Eur Rev Med Pharmacol Sci. 2019;23:397–401. doi: 10.26355/eurrev_201901_16788. - DOI - PubMed
    1. Rao DN, Mason RP. Generation of nitro radical anions of some 5-nitrofurans, 2- and 5-nitroimidazoles by norepinephrine, dopamine, and serotonin. A possible mechanism for neurotoxicity caused by nitroheterocyclic drugs. J Biol Chem. 1987;262:11731–6. doi: 10.1016/S0021-9258(18)60872-5. - DOI - PubMed
    1. Daneman N, Cheng Y, Gomes T, Guan J, Mamdani MM, Saxena FE, et al. Metronidazole-associated neurologic events: A nested-case control study. Clin Infect Dis. 2021;72:2095–100. doi: 10.1093/cid/ciaa395. - DOI - PMC - PubMed
    1. Kim E, Na DG, Kim EY, Kim JH, Son KR, Chang KH. MR imaging of metronidazole-induced encephalopathy: Lesion distribution and diffusion-weighted imaging findings. AJNR Am J Neuroradiol. 2007;28:1652–8. doi: 10.3174/ajnr.A0655. - DOI - PMC - PubMed
    1. Cramer SC, Stegbauer KC, Schneider A, Mukai J, Maravilla KR. Decreased diffusion in central pontine myelinolysis. AJNR Am J Neuroradiol. 2001;22:1476–9. - PMC - PubMed

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