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Review
. 2022 Mar;46(1):296-303.
doi: 10.1007/s12639-021-01425-7. Epub 2021 Aug 2.

An analysis of Plasmodium falciparum-K13 mutations in India

Laxman Kumar Murmu  1 , Tapan Kumar Barik  1
Affiliations
Review

An analysis of Plasmodium falciparum-K13 mutations in India

Laxman Kumar Murmu et al. J Parasit Dis. 2022 Mar.

Abstract

Malaria is one of the deadliest parasitic diseases in human. Currently, Artemisinin-based combination therapy is considered as the gold standard and most common treatment option. However, the origin and transmission of Plasmodium falciparum from the Greater Mekong Subregion, which has decreased artemisinin (ART) sensitivity, has sparked global concern. The reduced ART sensitivity has been associated with mutations in the Atpase6 and Kelch13 propeller domain of Plasmodium falciparum. A molecular marker is critically needed to monitor the spread of artemisinin resistance. In this article, we reviewed the k13 mutations and potential marker for ART resistance in India. There have been fourteen mutations identified, three of which have been validated by the World Health Organization (WHO) as artemisinin resistance mutations (F446I, R561H/C, and R539T). Among them, the role of F446I and R561H/C in ART resistance is conflicting. R539T and G625R mutation has been identified as an ART- resistance marker in India.

Keywords: Artemisinin; India; K13 Mutation; Sensitivity.

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Conflict of interest statement

Conflicts of interestThe authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
The map shows India’s region with death due to malaria (Source: NVBDCP)
Fig. 2
Fig. 2
Map showing the reported malaria cases due to Plasmodium falciparum in India Source: NVBDCP and reported k-13 validated mutations
See this image and copyright information in PMC

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