Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep-Oct;25(5):432-437.
doi: 10.4103/ijem.ijem_196_21. Epub 2022 Jan 12.

Impact of Anti-Diabetic Medications on Quality of Life in Persons with Type 2 Diabetes Mellitus

Manash P Baruah  1 , Ananya Bhowmick  1 , Seema Bhuyan  1 , Sonali B Bhuyan  2 , Jumi Deka  1 , Smriti Sikha Bora  1
Affiliations

Impact of Anti-Diabetic Medications on Quality of Life in Persons with Type 2 Diabetes Mellitus

Manash P Baruah et al. Indian J Endocrinol Metab. 2021 Sep-Oct.

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) has been found to be associated with poor quality of life (QOL). The aim of this study was to measure QOL in T2DM patients and examine if the patients' socio demographic, diabetes-related clinical characteristics and insulin usage are associated with better quality of life.

Materials and methods: This clinic based cross-sectional study analyzed data from outpatients with T2DM attending a referral clinic between January and June 2016. Association between Diabetes Attitudes, Wishes and Needs (DAWN) QOL and few demographic, socioeconomic, clinical and biochemical predictors were examined using multivariate logistic regression model. A total of 518 patients completed the interview.

Results: The HbA1c level of insulin ± oral anti-diabetic (OAD) cohort was significantly lower (7.89 ± 1.98) than the OAD cohort (8.79 ± 1.96), P < 0.001. Compared to their counterparts in the OAD cohort, patients on insulin were older with longer duration of diabetes mellitus. Co-morbid confounders like obesity, hypoglycemia, and blood pressure control or socio demographic confounders like income, education were almost similar in both the cohorts. The incidence of hypertension, coronary artery disease (CAD) and statin usage was significantly higher in the insulin cohort. The overall composite DAWN QOL scores of the insulin ± OAD cohort (25.42 ± 4.35) was marginally higher than that of the OAD cohort (23.62 ± 5.06) (P = 0.067). Analog insulin users were also found to have significantly higher composite DAWN QOL scores compared to human insulin users (25.77 ± 5.73 vs.24.13 ± 4.88, P = 0.037).

Conclusions: The insulin cohort, despite being older and having longer duration of diabetes, had significantly higher diet compliance score, and enhanced QOL owing to better diabetes-related knowledge and treatment adherence characteristics than non-insulin users. Questionnaires-based evaluation of QOL can provide better understanding of the patient's experience of the illness, self-care, psychological and emotional functioning, and choice of therapeutic modality enhancing the quality of care.

Keywords: Diabetes mellitus; India; insulin; patient-reported outcomes; quality of life.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

References

    1. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9(th) edition. Diabetes Res Clin Pract. 2019;157:107843. - PubMed
    1. Barnard RK, Santhosh YL. Impact of clinical pharmacist provided patient education on QOL outcome in type II diabetes mellitus in rural population. Asian J Pharm Clin Res. 2011;4:15–20.
    1. Barnard KD, Skinner TC, Peveler R. The prevalence of co morbid depression in adults with Type 1 diabetes: Systematic literature review. Diabet Med. 2006;23:445–8. - PubMed
    1. Hanninen BP, Agarwal G, Khandelwal D, Dutta D, Kalra S, Taparia P, et al. Occurrence and predictors of depression and poor quality of life among patients with type-2 diabetes: A Northern India perspective. Indian J Endocrinol Metab. 2017;21:564–9. - PMC - PubMed
    1. Hanninen J, Takala J, Keinanen-Kiukaanniemi S. Good continuity of care may improve quality of life in Type 2 diabetes. Diabetes Res Clin Pract. 2001;51:21–7. - PubMed