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. 2022 Oct 27;60(4):2103160.
doi: 10.1183/13993003.03160-2021. Print 2022 Oct.

Child maltreatment, anxiety and depression, and asthma among British adults in the UK Biobank

Yueh-Ying Han  1 , Qi Yan  2 , Wei Chen  1 , Juan C Celedón  3
Affiliations

Child maltreatment, anxiety and depression, and asthma among British adults in the UK Biobank

Yueh-Ying Han et al. Eur Respir J. .

Abstract

Background: Child maltreatment is associated with asthma in adults. We examined whether lifetime major depressive disorder (MDD) or lifetime generalised anxiety disorder (GAD) mediate an association between child maltreatment and current asthma among 81 105 British adults in the UK Biobank who completed a mental health survey and had complete data on child maltreatment, GAD, MDD, asthma and relevant covariates but no diagnosis of chronic obstructive pulmonary disease.

Methods: Child maltreatment was ascertained based on answers to the five questions in the Childhood Trauma Screener. Two mediators, lifetime MDD and GAD, were assessed based on the Composite International Diagnostic Interview Short Form. Current asthma was defined as physician-diagnosed asthma and wheeze or whistling in the chest in the previous year. Logistic regression was used for the multivariable analysis of child maltreatment and current asthma, and a mediation analysis was conducted to estimate the contributions of lifetime MDD and lifetime GAD to the child maltreatment-current asthma association.

Results: In a multivariable analysis, any child maltreatment was associated with asthma (adjusted OR 1.22, 95% CI 1.15-1.28; p<0.01). In a mediation analysis adjusted for household income, educational attainment, smoking status, pack-years of smoking and other covariates, lifetime GAD and lifetime MDD explained 21.8% and 32.5%, respectively, of the child maltreatment-current asthma association. Similar results were obtained after excluding current smokers and former smokers with ≥10 pack-years of smoking from the mediation analysis.

Conclusion: Our findings suggest that GAD and MDD mediate an association between child maltreatment and asthma in adults, independently of smoking.

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Conflict of interest statement

Conflicts of interest: J.C. Celedón has received research materials from GSK and Merck (inhaled steroids) and Pharmavite (vitamin D and placebo capsules) to provide medications free of cost to participants in US National Institutes of Health-funded studies, unrelated to this work. The other authors have no conflicts of interest to declare.

Figures

Figure 1.
Figure 1.
Mediation analysis for any child maltreatment, major depression disorder (mediator, M1), generalized anxiety disorder (M2), major depression disorder or generalized anxiety disorder and current asthma. Mediation analyses were performed for major depression disorder (panel A), generalized anxiety disorder (panel B), and join effect for major depression or generalized anxiety disorder (panel C) separately. Models adjusted for age at recruitment, sex, race, education, annual household income, body mass index, smoking status, pack-years of cigarette smoking, and serum level of C-reactive protein. aP <0.01
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References

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