The TARGET trial as a plea for model-informed precision dosing of piperacillin/tazobactam in patients with sepsis

Matthias Gijsen^{1

2}, Erwin Dreesen³, Joost Wauters^{4

5}, Yves Debaveye^{6

7}, Isabel Spriet^{3

8}

Affiliations

¹ Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. matthias.gijsen@uzleuven.be.
² Pharmacy Department, University Hospitals Leuven, Leuven, Belgium. matthias.gijsen@uzleuven.be.
³ Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
⁴ Department of General Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.
⁵ Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000, Leuven, Belgium.
⁶ Department of Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium.
⁷ Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
⁸ Pharmacy Department, University Hospitals Leuven, Leuven, Belgium.

Comment

Matthias Gijsen et al. Intensive Care Med. 2022 Jun.

. 2022 Jun;48(6):768-769.

doi: 10.1007/s00134-022-06679-0. Epub 2022 Mar 17.

Matthias Gijsen^{1

2}, Erwin Dreesen³, Joost Wauters^{4

5}, Yves Debaveye^{6

7}, Isabel Spriet^{3

8}

¹ Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. matthias.gijsen@uzleuven.be.
² Pharmacy Department, University Hospitals Leuven, Leuven, Belgium. matthias.gijsen@uzleuven.be.
³ Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
⁴ Department of General Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.
⁵ Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000, Leuven, Belgium.
⁶ Department of Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium.
⁷ Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
⁸ Pharmacy Department, University Hospitals Leuven, Leuven, Belgium.

No abstract available

Comment on

Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial.
Hagel S, Bach F, Brenner T, Bracht H, Brinkmann A, Annecke T, Hohn A, Weigand M, Michels G, Kluge S, Nierhaus A, Jarczak D, König C, Weismann D, Frey O, Witzke D, Müller C, Bauer M, Kiehntopf M, Neugebauer S, Lehmann T, Roberts JA, Pletz MW; TARGET Trial Investigators. Hagel S, et al. Intensive Care Med. 2022 Mar;48(3):311-321. doi: 10.1007/s00134-021-06609-6. Epub 2022 Feb 1. Intensive Care Med. 2022. PMID: 35106617 Free PMC article. Clinical Trial.

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