Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun;28(6):964-970.
doi: 10.1111/cns.13814. Epub 2022 Mar 18.

α-tocopherol pretreatment alleviates cerebral ischemia-reperfusion injury in rats

Shitao Lv  1 , Haiyan Yang  1 , Pengcheng Jing  2 , Haiying Song  3
Affiliations

α-tocopherol pretreatment alleviates cerebral ischemia-reperfusion injury in rats

Shitao Lv et al. CNS Neurosci Ther. 2022 Jun.

Abstract

α-tocopherol showed antioxidant, anti-inflammatory and anti-apoptotic abilities in rat brain tissue, thus alleviating cerebral ischemia-reperfusion injury-induced nerve damage.

Keywords: apoptosis; cerebral; inflammation; ischemia-reperfusion injury; oxidative stress; α-tocopherol.

PubMed Disclaimer

Conflict of interest statement

The authors declared no conflict of interest.

Figures

FIGURE 1
FIGURE 1
α‐TOH improved nerve damage symptoms in CIRI rats. (A) Infarct area of brain tissue in rats; (B) NDS of rats in four groups; (C) cerebral water content; (D) γ‐aminobutyric acid in brain tissue of rats (“*” means p < 0.05)
FIGURE 2
FIGURE 2
α‐TOH reduced the level of oxidative stress in the brain tissue of CIRI rats. Activities of SOD (A), GSH‐Px (B), NOS (C), NO (D), ATP (E), and NAD+/NADP ratio (F) were detected to determine the oxidative stress in the brain tissue of CIRI rats (“*” means p < 0.05)
FIGURE 3
FIGURE 3
α‐TOH reduced inflammation levels in CIRI rats. IL‐1β (A), IL‐6 (B), and TNF‐α (C) in rat serum were detected by ELISA; mRNA of IL‐1β (D), IL‐6 (E), and TNF‐α (F) in rat brain tissue were detected by RT‐PCR (“*” means p < 0.05)
FIGURE 4
FIGURE 4
α‐TOH inhibited cell apoptosis in the brain tissue of CIRI rats. (A) TUNEL staining results of brain tissue in rats (magnification: 200×); (B–E) mRNA expression of caspase3, caspase9, Bax, and Bcl‐2 in brain tissue (“*” means p < 0.05)
See this image and copyright information in PMC

References

    1. Spence JD. Stroke prevention: a lifetime of lessons. Stroke. 2020;51(7):2255‐2262. - PubMed
    1. Niu L, Jiang SW, Wang Y, et al. Total cholesterol affects the outcome of patients with anterior cerebral artery‐occluded acute ischemic stroke treated with thrombolysis. Eur Rev Med Pharmacol Sci. 2020;24(3):1504‐1514. - PubMed
    1. Towfighi A, Ovbiagele B, El HN, et al. Poststroke depression: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2017;48(2):e30‐e43. - PubMed
    1. Lee M, Saver JL, Liao HW, Lin CH, Ovbiagele B. Pioglitazone for secondary stroke prevention: a systematic review and meta‐analysis. Stroke. 2017;48(2):388‐393. - PubMed
    1. Charidimou A, Turc G, Oppenheim C, et al. Microbleeds, cerebral hemorrhage, and functional outcome after stroke thrombolysis. Stroke. 2017;48(8):2084‐2090. - PubMed