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Comment
. 2022 Mar 18:11:e77749.
doi: 10.7554/eLife.77749.

A gradual path to mortality

Na Yang  1 , Payel Sen  1
Affiliations
Comment

A gradual path to mortality

Na Yang et al. Elife. .

Abstract

Many of the features associated with senescence appear steadily over time before cells stop dividing.

Keywords: chromosomes; epithelial to mesenchymal transition; gene expression; genetics; genomics; human; replicative senescence; senescence.

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Conflict of interest statement

NY, PS No competing interests declared

Figures

Figure 1.
Figure 1.. The journey to replicative senescence.
Healthy cells cultured in the laboratory (left) will undergo continuous rounds of division until they reach a state of growth arrest called replicative senescence (right; shown in blue). To begin with (early and early-middle stages), cells express factors associated with cell cycle progression and growth as well as proteins that maintain chromatin stability. As they progress towards replicative senescence (middle-late stage), they undergo an epithelial-to-mesenchymal transition (EMT) and change their cell identity: this transition is driven by the growth factor protein TGFβ2 and the protein complex YAP1/TEAD1. As cells near replicative senescence (late stage), they exhibit a pro-inflammatory phenotype and secrete cytokines, in addition to expressing a beta-galactosidase enzyme which is detected by a reaction that turns cells blue.
See this image and copyright information in PMC

Comment on

  • Novel insights from a multiomics dissection of the Hayflick limit.
    Chan M, Yuan H, Soifer I, Maile TM, Wang RY, Ireland A, O'Brien JJ, Goudeau J, Chan LJG, Vijay T, Freund A, Kenyon C, Bennett BD, McAllister FE, Kelley DR, Roy M, Cohen RL, Levinson AD, Botstein D, Hendrickson DG. Chan M, et al. Elife. 2022 Feb 4;11:e70283. doi: 10.7554/eLife.70283. Elife. 2022. PMID: 35119359 Free PMC article.

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