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. 2022 Jun;92(6):1461-1465.
doi: 10.1111/ans.17602. Epub 2022 Mar 18.

The health-related quality of life changes following surgery in patients with colorectal cancer: a longitudinal study

Howard Tang  1 , Alex Besson  1 , Irene Deftereos  1   2 , Bede Mahon  1 , Jin Cho  3 , Ian Faragher  3 , Karla Gough  4   5 , Justin Yeung  2   3   6
Affiliations

The health-related quality of life changes following surgery in patients with colorectal cancer: a longitudinal study

Howard Tang et al. ANZ J Surg. 2022 Jun.

Abstract

Background: Colorectal cancer (CRC) is commonly treated with surgery and its success is frequently defined by cure rates. Impact on other aspects of health and wellbeing are less frequently considered in clinical practice. Patient-reported outcome measures (PROMs) provide a useful means of assessing such impacts. This study examines changes in health-related quality of life (HRQoL) after surgical resection using PROMs.

Methods: A prospective, longitudinal study was undertaken in 49 adults receiving curative surgery for CRC. Participants completed the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) before surgery, and at 2 to 4 weeks, 3 and 6 months post-surgery. Linear mixed models were used to analyse FACT-C wellbeing and subscale scores.

Results: Patients reported a clinically important deterioration in functional and physical wellbeing 2 to 4 weeks post-surgery (both P < 0.05); differences at 6 months after surgery were trivial. Conversely, patients reported clinically important improvement in emotional wellbeing at 2 to 4 weeks post-surgery; this improvement was sustained at 3 and 6 months post-surgery (all P < 0.05). For social wellbeing and colorectal cancer-specific concerns, changes from before surgery at follow-up assessments were not statistically significant (all P > 0.05).

Conclusion: While physical aspects of HRQoL are affected in the short term by CRC surgery, clinically significant improvement in emotional wellbeing are reported early (2 to 4 weeks post-surgery). Future research may help identify patients who are at greater risk of surgical impacts on health and wellbeing.

Keywords: colorectal cancer surgery; health related quality of life; patient-reported outcome measures.

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References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018; 68: 394-424.
    1. Allvin R, Berg K, Idvall E, Nilsson U. Postoperative recovery: a concept analysis. J. Adv. Nurs. 2007; 57: 552-8.
    1. Lee L, Tran T, Mayo NE, Carli F, Feldman LS. What does it really mean to “recover” from an operation? Surgery 2014; 155: 211-6.
    1. Weldring T, Smith SM. Patient-reported outcomes (PROs) and patient-reported outcome measures (PROMs). Health Serv Insights. 2013; 6: 61-8.
    1. McNair AG, Whistance RN, Forsythe RO et al. Synthesis and summary of patient-reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery. Color. Dis. 2015; 17: O217-29.

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