Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19

Griffith B Perkins¹, Matthew Tunbridge², Tania Salehi², Cheng Sheng Chai³, Svjetlana Kireta², Julie Johnston², Daniella Penko², Jodie Nitschke², Arthur Eng Lip Yeow⁴, Zahraa Al-Delfi⁴, Christopher J Drogemuller⁵, Pablo Garcia-Valtanen⁴, Makutiro G Masavuli⁴, Christopher M Hope⁶, Julian Singer⁷, Anupriya Aggarwal⁸, Alberto Ospina Stella⁸, Stuart G Turville⁸, Plinio R Hurtado², Simon C Barry⁶, Pravin Hissaria⁹, Branka Grubor-Bauk⁴, Steven J Chadban⁷, P Toby Coates¹⁰

Affiliations

¹ Department of Molecular and Biomedical Sciences, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia; Immunology, SA Pathology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
² Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
³ Department of Molecular and Biomedical Sciences, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.
⁴ Viral Immunology Group, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Basil Hetzel Institute for Translational Health Research, Woodville, South Australia, Australia.
⁵ Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Discipline of Medicine, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
⁶ Molecular Immunology, Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Paediatric Medicine, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
⁷ Kidney Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Kidney Node, Charles Perkins Centre, University of Sydney, New South Wales, Australia.
⁸ Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
⁹ Immunology, SA Pathology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia; Discipline of Medicine, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Department of Allergy and Immunology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
¹⁰ Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Discipline of Medicine, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia. Electronic address: Toby.Coates@sa.gov.au.

PMID: 35304094
PMCID: PMC8923876
DOI: 10.1016/j.kint.2022.02.015

Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19

Griffith B Perkins et al. Kidney Int. 2022 May.

. 2022 May;101(5):1077-1080.

doi: 10.1016/j.kint.2022.02.015. Epub 2022 Mar 16.

Authors

Affiliations

¹ Department of Molecular and Biomedical Sciences, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia; Immunology, SA Pathology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
² Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
³ Department of Molecular and Biomedical Sciences, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.
⁴ Viral Immunology Group, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Basil Hetzel Institute for Translational Health Research, Woodville, South Australia, Australia.
⁵ Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Discipline of Medicine, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
⁶ Molecular Immunology, Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Paediatric Medicine, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
⁷ Kidney Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Kidney Node, Charles Perkins Centre, University of Sydney, New South Wales, Australia.
⁸ Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
⁹ Immunology, SA Pathology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia; Discipline of Medicine, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Department of Allergy and Immunology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
¹⁰ Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Discipline of Medicine, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia. Electronic address: Toby.Coates@sa.gov.au.

PMID: 35304094
PMCID: PMC8923876
DOI: 10.1016/j.kint.2022.02.015

No abstract available

Keywords: BNT162b2; COVID-19; ChAdOx1; SARS-CoV-2; close household contact; cohabitant; kidney transplant; ring vaccination.

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Figures

**Figure 1**
**Immune response of kidney transplant recipients (KTRs; n = 46) and close household contacts (CHCs; n = 46) to 2 doses of coronavirus disease 2019 (COVID-19) vaccine.** KTR and CHC were concurrently vaccinated with the BNT162b2 or ChAdOx1 vaccine. Blood samples collected at baseline, 3 weeks after dose 1, and 3 weeks after dose 2. (a) Log-scale longitudinal comparison of serum spike-specific antibody titers, reported as area under the curve (AUC) units. Circles represent AUC individual participant values, with mean value denoted by black bars. (b) Log-scale comparison of serum anti–severe acute respiratory syndrome coronavirus 2 (αSARS-CoV-2) receptor-binding domain (RBD) IgG titers 3 weeks after dose 2 in KTRs and CHCs. Results below the detection threshold are plotted as 0.4 U/ml and marked with a dashed line. The percentage of individuals above the detection limit is indicated. (c) Serological neutralization end point cutoff titers in KTRs and CHCs. Data points represent the highest serum dilution factor that yielded 50% inhibition of live virus (Wuhan) infection. Twenty was the minimum dilution tested for all samples, and the percentage of individuals achieving a neutralization titer of ≥20 is indicated. Individuals who did not achieve neutralization at a dilution factor of ≥20 were considered negative and ascribed a value of zero, marked with a dashed line. (d) Vaccine-induced interferon-γ (IFN-γ)–secreting T-cell response. Isolated peripheral blood mononuclear cells (PBMCs) were stimulated for 18 hours with spike glycoprotein-derived peptides and the frequency of IFN-γ–secreting cells measured as spot-forming units (SFUs) by enzyme-linked immunoabsorbent spot assay. SFUs at baseline were subtracted from SFUs 3 weeks after dose 2 to determine the change in spike-reactive, IFN-γ–secreting T-cell frequencies in response to vaccination. Differences between groups tested using the 2-tailed Mann-Whitney test. NS, not significant. ∗∗∗∗P < 0.0001. ΔIFN-γ, change in interferon-γ.

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References

1. Phanish M., Ster I.C., Ghazanfar A., et al. Systematic review and meta-analysis of COVID-19 and kidney transplant recipients, the South West London Kidney Transplant Network experience. Kidney Int Rep. 2021;6:574–585. - PMC - PubMed
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1. Prendecki M., Thomson T., Clarke C.L., et al. Immunological responses to SARS-CoV-2 vaccines in kidney transplant recipients. Lancet. 2021;398:1482–1484. - PMC - PubMed
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1. Cox R. Correlates of protection to influenza virus, where do we go from here? Hum Vacc Immunother. 2013;9:405–408. - PMC - PubMed

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Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19

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Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19

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