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Case Reports
. 2022 Mar;22(2):169-171.
doi: 10.7861/clinmed.2021-0789.

Lessons of the month 2: A case of inappropriate drug-drug interaction in kidney transplant

Min-Hui Tan  1 , Seow-Yeing Yee  2 , Rosnawati Yahya  2
Affiliations
Case Reports

Lessons of the month 2: A case of inappropriate drug-drug interaction in kidney transplant

Min-Hui Tan et al. Clin Med (Lond). 2022 Mar.

Abstract

Carbamazepine remains a first-line antiepileptic medication for the treatment of partial seizures. Despite its widespread use, carbamazepine has significant neurotoxicity and hypersensitivity reactions. We report a case of a patient post-kidney transplant who was on regular carbamazepine for childhood epilepsy and developed nystagmus, diplopia and a broad-base gait after receiving diltiazem. Understanding of the interaction between diltiazem and carbamazepine is necessary to prevent the neurotoxic effects.

Keywords: carbamazepine; diltiazem; drug interaction; kidney transplant; neurotoxicity.

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