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. 2022 Sep;110(9):2039-2049.
doi: 10.1002/jbm.b.35058. Epub 2022 Mar 19.

A porcine cholecystic extracellular matrix conductive scaffold for cardiac tissue repair

Reshma S Nair  1 , Praveen K Sobhan  2 , Sachin J Shenoy  3 , Mukund A Prabhu  4 , Aswathy M Rema  2 , Surya Ramachandran  5 , Surendran C Geetha  1 , Kanakarajan V Pratheesh  1 , Manjula P Mony  1 , Reshmi Raj  1 , Thapasimuthu V Anilkumar  1   6
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A porcine cholecystic extracellular matrix conductive scaffold for cardiac tissue repair

Reshma S Nair et al. J Biomed Mater Res B Appl Biomater. 2022 Sep.

Abstract

Cardiac tissue engineering using cells, scaffolds or signaling molecules is a promising approach for replacement or repair of damaged myocardium. This study addressed the contemporary need for a conductive biomimetic nanocomposite scaffold for cardiac tissue engineering by examining the use of a gold nanoparticle-incorporated porcine cholecystic extracellular matrix for the same. The scaffold had an electrical conductivity (0.74 ± 0.03 S/m) within the range of native myocardium. It was a suitable substrate for the growth and differentiation of cardiomyoblast (H9c2) as well as rat mesenchymal stem cells to cardiomyocyte-like cells. Moreover, as an epicardial patch, the scaffold promoted neovascularisation and cell proliferation in infarcted myocardium of rats. It was concluded that the gold nanoparticle coated cholecystic extracellular matrix is a prospective biomaterial for cardiac tissue engineering.

Keywords: biocompatibility; cardiomyocyte-like cells; differentiation; epicardial graft; myocardial infarction.

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References

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