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. 2022 Apr;10(4):e36-e37.
doi: 10.1016/S2213-2600(22)00060-1. Epub 2022 Mar 16.

Effects of SARS-CoV-2 on prenatal lung growth assessed by fetal MRI

Sophia Stoecklein  1 , Vanessa Koliogiannis  2 , Tobias Prester  2 , Thomas Kolben  3 , Magdalena Jegen  3 , Christoph Hübener  3 , Uwe Hasbargen  3 , Andreas Flemmer  4 , Olaf Dietrich  2 , Regina Schinner  2 , Julien Dinkel  2 , Nicola Fink  2 , Maximilian Muenchhoff  5 , Susan Hintz  6 , Maria Delius  3 , Sven Mahner  3 , Jens Ricke  2 , Anne Hilgendorff  7
Affiliations

Effects of SARS-CoV-2 on prenatal lung growth assessed by fetal MRI

Sophia Stoecklein et al. Lancet Respir Med. 2022 Apr.

Erratum in

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Conflict of interest statement

SS, VK, JR, and AH contributed equally. TK holds stock of Roche and Biontech and has a relative who is employed at Roche. SM is in the advisory board of, and receives research support, honoraria, and travel expenses from AbbVie, AstraZeneca, Clovis, Eisai, GlaxoSmithKline, Medac, Merck, Novartis, Olympus, PharmaMar, Pfizer, Roche, Sensor Kinesis, Teva, and Tesaro. All other authors declare no competing interests. This work was supported by the programme Physician Scientists for Groundbreaking Projects at Helmholtz Zentrum München (Munich, Germany) and part of the research programme GRK 2338: Targets in Toxicology. The funders of the study had no role in data collection, data analysis, data interpretation, writing of the manuscript, or the decision to submit it for publication.

Figures

Figure
Figure
Effects of SARS-CoV-2 on fetal lung volume and bodyweight (A) 50th percentile values, 95% confidence level, and 5% confidence level of total fetal lung volume (mL) over gestational age (weeks at MRI), and the trend observed in pregnant women with SARS-CoV-2 infection. (B) 50th percentile reference values of estimated fetal bodyweight (g) over gestational age (weeks at MRI) and the trend observed in pregnant women with SARS-CoV-2 infection. (C) 50th percentile reference values of fetal lung volume-to-bodyweight ratio over gestational age (weeks at MRI) and the trend observed in pregnant women with SARS-CoV-2 infection. (D) Fetal lung volume normalised by fetal bodyweight (expressed as a percentage of 50th percentile reference value) with timepoint of infection in the third trimester vs timepoint of infection in the first or second trimester vs a site-specific, SARS-CoV-2-negative control group.
See this image and copyright information in PMC

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