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. 2022 Aug;48(8):1799-1806.
doi: 10.1016/j.ejso.2022.03.006. Epub 2022 Mar 11.

Treatment intention and outcome in patients with simultaneously diagnosed liver and lung metastases from colorectal cancer

Jennie Engstrand  1 , Johanna Sterner  2 , Kristina Hasselgren  3 , Cecilia Stromberg  4 , Christian Sturesson  4
Affiliations
Free article

Treatment intention and outcome in patients with simultaneously diagnosed liver and lung metastases from colorectal cancer

Jennie Engstrand et al. Eur J Surg Oncol. 2022 Aug.
Free article

Abstract

Background: The aim was to assess the likelihood of patients with simultaneously diagnosed liver and lung metastases (SLLM) from colorectal cancer (CRC) to receive the curative treatment decided upon multidisciplinary team meeting (MDT) and to elaborate on the reasons for treatment intention failure and survival outcomes depending on final treatment strategy.

Method: The study included a retrospective review of all patients discussed at the MDT at a single centre between 2010 and 2018 to identify all patients presenting with SLLM from CRC. Treatment intention, actual treatment outcome and reasons for treatment failure was documented. Descriptive and survival statistics were applied.

Results: Of the 160 patients who had SLLM, resection of all metastatic sites was deemed possible in 107 patients (67%) of whom 39 patients (36%) finalized the curative treatment plan. The most common reason for noncompliance with management recommendations was disease progression or recurrence. Complete resection resulted in longer survival compared to patients who did not undergo resection of all metastatic sites with median survival of 63 and 27 months, respectively (p < 0.001).

Conclusion: A low proportion of patients completed the initially intended curative resections. Simultaneous resection of liver/lung metastases and primary tumour might increase the proportion of fulfilled hepatopulmonary resections.

Keywords: Colorectal cancer; Liver metastases; Lung metastases; Simultaneous metastases; Surgery.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: JE was funded by Ruth and Richard Julin Foundation and Region Stockholm (clinical postdoctoral appointment). None of the funding sources had any role in study design, in the collection, analysis and interpretation of data or in the writing of the report. The other authors have no declaration of interest.

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