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Review
. 2022 Sep;18(36):e2200291.
doi: 10.1002/smll.202200291. Epub 2022 Mar 20.

Progress in Stimuli-Responsive Biomaterials for Treating Cardiovascular and Cerebrovascular Diseases

Christos Tapeinos  1 , Han Gao  1   2 , Tomás Bauleth-Ramos  1   2 , Hélder A Santos  1   2
Affiliations
Review

Progress in Stimuli-Responsive Biomaterials for Treating Cardiovascular and Cerebrovascular Diseases

Christos Tapeinos et al. Small. 2022 Sep.

Abstract

Cardiovascular and cerebrovascular diseases (CCVDs) describe abnormal vascular system conditions affecting the brain and heart. Among these, ischemic heart disease and ischemic stroke are the leading causes of death worldwide, resulting in 16% and 11% of deaths globally. Although several therapeutic approaches are presented over the years, the continuously increasing mortality rates suggest the need for more advanced strategies for their treatment. One of these strategies lies in the use of stimuli-responsive biomaterials. These "smart" biomaterials can specifically target the diseased tissue, and after "reading" the altered environmental cues, they can respond by altering their physicochemical properties and/or their morphology. In this review, the progress in the field of stimuli-responsive biomaterials for CCVDs in the last five years, aiming at highlighting their potential as early-stage therapeutics in the preclinical scenery, is described.

Keywords: ischemic stroke; myocardial infarction; smart nanoparticles; stimuli-responsive hydrogels; tissue engineering.

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References

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