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. 2022 Jul;47(7):556-557.
doi: 10.1016/j.tibs.2022.03.005. Epub 2022 Mar 17.

System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory

Marek A Budzyński  1 , Sheila S Teves  2
Affiliations
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System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory

Marek A Budzyński et al. Trends Biochem Sci. 2022 Jul.

Abstract

Topoisomerase 1 (Top1) relieves torsional stress on DNA, including from RNA Polymerase II (Pol II) transcription. A new study by Wiegard et al. uncovers an unexpected role of Top1 in the appropriate clearance of Pol II from mitotic DNA, allowing for a reset of transcriptional memory in the daughter cells.

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