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Comparative Study
. 1986 Aug;5(8):1903-11.
doi: 10.1002/j.1460-2075.1986.tb04443.x.

Identification and characterization of the protein encoded by the human c-myb proto-oncogene

K H Klempnauer, C Bonifer, A E Sippel
Comparative Study

Identification and characterization of the protein encoded by the human c-myb proto-oncogene

K H Klempnauer et al. EMBO J. 1986 Aug.

Abstract

We have identified the product of the human c-myb proto-oncogene as a 80,000-Mr protein, p80c-myb, by using polyclonal and monoclonal antibodies raised against a bacterially synthesized polypeptide from the amino terminus of the viral myb protein. p80c-myb shares at least two distinct antigenic sites with the amino terminal region of the v-myb protein. p80c-myb is found only in hematopoietic cells or in cells that contain amplified c-myb genes. Like the chicken myb proteins, p80c-myb is a nuclear DNA-binding protein that is predominantly associated with chromatin and exhibits a short half-life of approximately 1 hour.

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