Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb;54(1):12-16.
doi: 10.5152/eurasianjmed.2022.20349.

Comparison of Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging in Patients with Prostate Biopsy Indications

Mehmet Sefa Altay  1 , Fatih Özkaya  2 , Şaban Oğuz Demirdöğen  1 , Fevzi Bedir  1 , Hüseyin Kocatürk  1 , Ahmet Emre Cinislioğlu  1 , Sinan Yilmaz  3 , Turgut Yapanoğlu  2
Affiliations

Comparison of Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging in Patients with Prostate Biopsy Indications

Mehmet Sefa Altay et al. Eurasian J Med. 2022 Feb.

Abstract

Objective: This article aims to evaluate the efficacy of multiparametric magnetic resonance imaging before standard tru-cut biopsy in making prostate cancer diagnosis.

Materials and methods: A total of 160 patients with prostate biopsy indications were prospectively evaluated between May 2017 and October 2018. Multiparametric magnetic resonance imaging was taken after obtaining a written informed consent from all patients. Cognitive transrectal ultrasound-guided biopsy was performed based on multiparametric magnetic resonance imaging results. Standard tru-cut biopsy was included to reduce false-negative rate. Statistical analysis was performed using the Statistical Package for Social Sciences version 20.0 software.

Results: The mean age of the patients was 65.94 ± 7.90 (48-84) years. Around 19.37% of the patients had a specificity in the digital rectal exam. The mean prostate-specific antigen value of the patients with adenocarcinoma was 42.1 ng/mL and it was 10.2 ng/mL in patients with benign prostate hyperplasia. It was observed that the prostate-specific antigen values in prostatic adenocarcinomas were significantly higher than those in benign prostate hyperplasia (P < .001). The results of multiparametric magnetic resonance imaging and the biopsy were 100% similar in terms of zones in patients with adenocarcinoma. All of the biopsy results of the patients who were evaluated to have normal prostate tissue in multiparametric magnetic resonance imaging were evaluated as benign prostate hyperplasia; on the other hand, 13.6% of PI-RADS 2 lesions, 14% of PI-RADS 3 lesions, 31.8% of PI-RADS 4 lesions, and 85.7% of PI-RADS 5 lesions were determined to be adenocarcinoma. It was observed that the prevalence of adenocarcinoma increased as the risk elevated in multiparametric magnetic resonance imaging (P < .001).

Conclusion: Multiparametric magnetic resonance imaging evaluated by experienced radiologists may be instructive of urologists and reduce the need for unnecessary biopsies.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1.
Figure 1.
The distribution of Mp-MRI PI-RADS classification and the biopsy results. Mp-MRI, multiparametric magnetic resonance imaging; PI-RADS, prostate imaging reporting and data system.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Barsouk A, Padala SA, Vakiti A.et al. Epidemiology, staging and management of prostate cancer. Med Sci (Basel). 2020;8(3). 10.3390/medsci8030028) - DOI - PMC - PubMed
    1. Rawla P. Epidemiology of prostate cancer. World J Oncol. 2019;10(2):63 89. 10.14740/wjon1191) - DOI - PMC - PubMed
    1. Xiang J, Yan H, Li J, Wang X, Chen H, Zheng X. Transperineal versus transrectal prostate biopsy in the diagnosis of prostate cancer: a systematic review and meta-analysis. World J Surg Oncol. 2019;17(1):31. 10.1186/s12957-019-1573-0) - DOI - PMC - PubMed
    1. Hugosson J, Carlsson S, Aus G.et al. Mortality results from the Göteborg randomised population-based prostate-cancer screening trial. Lancet Oncol. 2010;11(8):725 732. 10.1016/S1470-2045(10)70146-7) - DOI - PMC - PubMed
    1. Norberg M, Egevad L, Holmberg L, Sparén P, Norlén BJ, Busch C. The sextant protocol for ultrasound-guided core biopsies of the prostate underestimates the presence of cancer. Urology. 1997;50(4):562 566. 10.1016/S0090-4295(97)00306-3) - DOI - PubMed

LinkOut - more resources