Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug 25;14(3):334-338.
doi: 10.4274/jcrpe.galenos.2022.2022-12-9. Epub 2022 Mar 21.

Diagnostic Power of Bilateral Inferior Petrosal Sinus Sampling with Desmopressin in Paediatric Cushing’s Disease

Manuel André Virú-Loza  1 , Andrea Venegas Quispe  2
Affiliations
Review

Diagnostic Power of Bilateral Inferior Petrosal Sinus Sampling with Desmopressin in Paediatric Cushing’s Disease

Manuel André Virú-Loza et al. J Clin Res Pediatr Endocrinol. .

Abstract

Objective: The aim of this study was to evaluate the diagnostic accuracy of bilateral inferior petrosal sinus sampling (BIPSS) with desmopressin for pediatric Cushing’s disease (CD).

Methods: We reviewed studies performed in children that evaluated the accuracy of BIPSS with desmopressin.

Results: All included studies were case series of children with adrenocorticotropin hormone (ACTH)-dependent Cushing’s syndrome. The overall accuracy of BIPSS before stimulation was 84.1% (37/44), and after stimulation it was 92.3% (36/39). The overall lateralizing accuracy of BIPSS was 50.0%.

Conclusion: Considering that available evidence is limited, it appears that BIPSS with desmopressin stimulation is accurate for the diagnosis of pediatric CD, but its lateralizing accuracy is probably not suitable for pediatric clinical practice.

Keywords: Petrosal sinus sampling; deamino arginine vasopressin; child; pituitary ACTH hypersecretion; systematic review.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Barbot M, Zilio M, Scaroni C. Cushing’s syndrome: Overview of clinical presentation, diagnostic tools and complications. Best Pract Res Clin Endocrinol Metab. 2020;34:101380. - PubMed
    1. Ferrigno R, Hasenmajer V, Caiulo S, Minnetti M, Mazzotta P, Storr HL, Isidori AM, Grossman AB, De Martino MC, Savage MO. Paediatric Cushing’s disease: Epidemiology, pathogenesis, clinical management and outcome. Rev Endocr Metab Disord. 2021;22:817–835. - PMC - PubMed
    1. Miller BS, Auchus RJ. Evaluation and Treatment of Patients with Hypercortisolism: A Review. JAMA Surg. 2020;155:1152–1159. - PubMed
    1. Lonser RR, Wind JJ, Nieman LK, Weil RJ, DeVroom HL, Oldfield EH. Outcome of surgical treatment of 200 children with cushing’s disease. J Clin Endocrinol Metab. 2013;98:892–901. - PMC - PubMed
    1. Moszczyńska E, Marczak E, Szalecki M, Kądziołka K, Roszkowski M, Zagata-Lesnicka P. The Effects of Sampling Lateralization on Bilateral Inferior Petrosal Sinus Sampling for Pediatric Cushing’s Disease-A Single Endocrinology Centre Experience and Review of the Literature. Front Endocrinol (Lausanne) 2021;12:650967. - PMC - PubMed

Substances