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. 1986 Oct;47(3):269-73.
doi: 10.1016/0303-7207(86)90120-6.

A renin-like enzyme in luteal tissue

R R Cabrera, D C Guardia, E De Vito

A renin-like enzyme in luteal tissue

R R Cabrera et al. Mol Cell Endocrinol. 1986 Oct.

Abstract

The aim of this study was to identify immunologically and biologically a renin-like enzyme (RLE) in rat corpora lutea (CL). The biological activity of partially purified extracts of CL was tested in vivo by injection into anesthetized pentolinium-treated rats, obtaining a pressor response similar to renal renin. The enzyme activity in vitro was inhibited to about 50% by pretreatment with a specific antibody against renal renin. When the extracts were incubated with angiotensinogen, the product was inhibited mainly by angiotensin I antibody. The fact that there was no change in RLE content in 24 or 48 h nephrectomized rats, suggested the idea of a local production rather than an active blood renin sequestration.

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