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. 2022 Mar 4:9:814381.
doi: 10.3389/fmed.2022.814381. eCollection 2022.

Global Research Status of Multiple Organ Dysfunction Syndrome During 2001-2021: A 20-Year Bibliometric Analysis

Peng-Yue Zhao  1   2 , Yun Xia  3 , Zheng-Bo Tao  4 , Song-Yan Li  1 , Zhi Mao  5 , Xing-Peng Yang  1 , Ren-Qi Yao  2   6 , Xiao-Hui Du  1
Affiliations

Global Research Status of Multiple Organ Dysfunction Syndrome During 2001-2021: A 20-Year Bibliometric Analysis

Peng-Yue Zhao et al. Front Med (Lausanne). .

Abstract

Background: Multiple Organ Dysfunction Syndrome (MODS) is a major cause of high morbidity and mortality among patients in intensive care units (ICU). Although numerous basic and clinical researches on MODS have been conducted, there is still a long way to go to prevent patients from entering this stage. To our knowledge, no bibliometric analyses of MODS have been reported, this study, therefore, was conducted to reveal MODS research status and trends during 2001-2021.

Methods: All relevant literature covering MODS during 2001-2021 were extracted from Web of Science. An online analysis platform of literature metrology was used to analyze the publication trends. VOSviewer software was used to collect and analyze the keywords and research hotspots related to MODS.

Results: As of July 31, 2021, a total of 994 MODS-related articles from 2001 to 2021 were identified. The United States accounted for the largest number of publications (31.1%), followed by China and Germany, with 186 and 75 publications, respectively. Among all the institutions, the University of Pittsburgh published the most papers related to MODS (21). Critical Care Medicine published the most papers in this field (106). Professor Moore EE, who had the most citation frequency (1847), made great achievements in MODS research. Moreover, analysis of the keywords identified three MODS research hotspot clusters: "mechanism-related research," "clinical research," and "diagnostic research."

Conclusions: The United States maintained a top position worldwide and made the most outstanding contribution in the MODS field. In terms of publication, China was next only to the United States, but there was a disproportion between the quantity of publications and citation frequency. The institution University of Pittsburgh and journal Critical Care Medicine represent the highest level of research in this field. During the 20 years from 2001 to 2021, basic MODS research has been in-depth yet progressed relatively slowly recently, but the outbreak of COVID-19 has to some extent set off an upsurge of clinical research in MODS field.

Keywords: MODS; bibliometric analysis; keywords; publication; research hotspots.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of literature selection and screening in this study.
Figure 2
Figure 2
The number of annual publications in MODS from 2001 to 2021.
Figure 3
Figure 3
The model fitting curves of growth trends of publications related to MODS. (A) Global; (B) the United States; (C) China; (D) Germany.
Figure 4
Figure 4
The contributions of different countries/regions to the research field concerning MODS. (A) The number of publications, citation frequency (×0.05), and H-index (×5) in the top 10 countries or regions. (B) The growth trends of the top 10 countries/regions in MODS from 2001 to 2021.
Figure 5
Figure 5
The cooperation of countries/regions in MODS from 2001 to 2021.
Figure 6
Figure 6
The contributions of different institutions focusing on MODS. (A) Distribution of top 10 institutions focusing on MODS; (B) The cooperation of institutions in MODS, the circle with a large size represented the institution that published more articles; (C) Distribution of institutions was presented according to the appearance for the average time.
Figure 7
Figure 7
The top 10 journals publishing research on MODS.
Figure 8
Figure 8
The analysis of keywords in publications of MODS. (A) Mapping of the keywords in the area of MODS. The words were divided into 3 cluster in accordance with different colors generated by default: mechanism research (right in red), clinical research (left in green) and diagnostics and laboratory research (up in blue). The circle with a large size represented the keywords that appeared at a high frequency; (B) Distribution of keywords was presented according to the appearance for the average time. The blue color represented early appearance and yellow color recent appearance. Two keywords co-occurred if they both occurred on the same line in the corpus file. The smaller the distance between two keywords, the larger the number of co-occurrences of the keywords.
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