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Review
. 2022;24(3):39-50.
doi: 10.1007/s11908-022-00776-3. Epub 2022 Mar 15.

Advances in Liver Transplantation for Persons with Human Immunodeficiency Infection

Rebecca N Kumar  1 , Valentina Stosor  2
Affiliations
Review

Advances in Liver Transplantation for Persons with Human Immunodeficiency Infection

Rebecca N Kumar et al. Curr Infect Dis Rep. 2022.

Abstract

Purpose of review: Advanced liver disease is a leading cause of non-AIDS-related morbidity and mortality in persons with HIV on antiretroviral therapy. As a result, persons with HIV are increasingly seeking liver transplantation.

Recent findings: With the availability of direct-acting antiviral hepatitis C therapies, there has been a shift in the indications for liver transplantation in persons with HIV, with non-alcoholic fatty liver disease now the leading indication over hepatitis C infection. Additionally, liver transplant outcomes have improved in persons with HIV-hepatitis C co-infection persons with HIV. Preliminary results of HIV-to-HIV liver transplantation show acceptable results although rates of post-transplant infections and malignancies are areas of concern.

Summary: Future studies of liver transplantation in persons with HIV should focus on long-term outcomes, especially in the context of steatohepatitis and co-existing morbidities like diabetes, hyperlipidemia, and cardiovascular disease and other prevalent diseases in an aging population.

Keywords: Hepatitis B virus; Hepatitis C virus; Human immunodeficiency virus; Liver disease; Liver transplantation; Non-alcoholic fatty liver disease.

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Conflict of interest statement

Conflict of InterestRebecca Kumar has received grants from Regeneron. Dr. Stosor has received grants from Eli Lilly and Company and the National Institutes of Health, speaker honorarium from Med Learning Group, and consulting fees from DiaSorin, Inc.

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