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. 2022 Mar 3:13:853606.
doi: 10.3389/fimmu.2022.853606. eCollection 2022.

Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation

Anthony J Leonardi  1 , Christos P Argyropoulos  2 , Adam Hamdy  3 , Rui B Proenca  4
Affiliations

Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation

Anthony J Leonardi et al. Front Immunol. .
No abstract available

Keywords: CD8; Fas; FasL; SARS-CoV-2; T cells; differentiation; feed-forward Loop; paracrine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Illustration of the Paracrine Fas/FasL differentiation and death system (A) Stimulation of a naive-rich pool of T-cells corresponding to a youthful repertoire (B) Stimulation of a more differentiated pool of T-cells (C) Stimulation of a pool of T-cells with few Tn, where the population will reach cytotoxic function more exuberantly (D) Proposed coherent type 2 Feed-Forward Loop of Fas-mediated differentiation and death (solid line), with a negative feedback loop on naive T cells from effector T cells (E) FFL error from coherent type 2 to incoherent type 2 in ALPS and the murine model Fas C194V due to a defect in CD95-mediated Apoptosis but not CD95-mediated differentiation. (Figure adapted with permission from Leonardi and Proenca, 2020).
See this image and copyright information in PMC

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