Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;11(1):84-89.
doi: 10.4103/jfmpc.jfmpc_576_21. Epub 2022 Jan 31.

Status of drug resistant tuberculosis among patients attending a tuberculosis unit of West Bengal: A record based cross-sectional study

Rekha Dutt  1 , Ritesh Singh  1 , Jitendra Majhi  1 , Gandhari Basu  2
Affiliations

Status of drug resistant tuberculosis among patients attending a tuberculosis unit of West Bengal: A record based cross-sectional study

Rekha Dutt et al. J Family Med Prim Care. 2022 Jan.

Abstract

Context: Tuberculosis (TB) is one of the main causes of death due to infectious diseases worldwide. Multidrug resistance/rifampicin resistance (MDR/RR) TB remains a public health crisis. India has the highest burden of tuberculosis and multidrug resistant TB (MDR TB) in the world. There is wide geographical variation in the epidemic and its trends that can be updated by regular reporting and sound surveillance systems. The current study tries to fill this gap by analyzing the data of TB patients from a Tuberculosis Unit, studying socio-demographic and clinical profile from December 2017 to November 2019 in Nadia district of West Bengal.

Aims: The aims of this work were to study socio-demographic and clinical profile of TB patients attending Tuberculosis Unit of West Bengal, and to find out factors associated with drug-resistant TB.

Settings and design: Record-based study from Tuberculosis Unit.

Methods: Records of all patients who undergo CBNAAT in TU are stored as monthly unit. We randomly selected 10 months from a period of December 2017 to November 2019 by using lot method. Data of all patients undergoing CBNAAT at Kalyani - Gayeshpur Tuberculosis Unit during randomly selected 10 months were accessed.

Statistical analysis used: Monthly data was entered in Microsoft Excel and descriptive tests of significance, proportions and Chi-square were applied.

Results: There was male preponderance for testing of tuberculosis. Seven percent of the TB suspects were HIV positive. The positivity rate of MTB by CBNAAT was 23%. Four percent of the samples were Rifampicin resistance. Tobacco consumption, contact with TB case and Diabetes were common risk factors of TB. Most of the information was missing in the records.

Conclusions: Most of Rifampicin Resistant cases showed very low Ct value in CBNAAT. Previous history of TB treatment and positive HIV status was significantly associated with RR TB. There is a need to capture complete information on the records of presumptive TB cases.

Keywords: CBNAAT; rifampicin resistance; tuberculosis.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Ten months data of presumptive TB patients accessed from a Tuberculosis Unit during period of December 2017 to November 2019
Figure 2
Figure 2
Tuberculosis sputum microscopy result of samples A and B from a ten months data
See this image and copyright information in PMC

References

    1. Global TB Report 2020. [Last accessed on 2021 Mar 24]. Available from: https://apps.who.int/iris/bitstream/handle/10665/336069/9789240013131-en... .
    1. Jaleta KN, Gizachew M, Gelaw B, Tesfa H, Getaneh A, Biadgo B. Rifampicin-resistant Mycobacterium tuberculosis among tuberculosis-presumptive cases at University of Gondar Hospital, northwest Ethiopia. Infect Drug Resist. 2017;10:185–92. - PMC - PubMed
    1. Revised National Tuberculosis Programme. [Last accessed on 2021 Mar 24];National Strategic Plan for Tuberculosis:2017-2025, Elimination by 2025. Ministry of Health and Family Welfare. 2017 March; Available from: https://www.tbcindia.gov.in/WriteReadData/National%20Strategic%20Plan%20... .
    1. Guidelines for Progmmatic Management of Drug Resistance in India. National Tuberculosis Elimination Programme, GOI. Mar, 2021. [Last accessed on 2021 Mar 24]. Available from: https://tbcindia.gov.in/showfile.php?lid=3590 .
    1. Scott L, Kerrigan M, Natasha G, Matilda N, Annelies V, Lan V, et al. Comparison of xpert MTB/RIF with other nucleic acid technologies for diagnosing pulmonary tuberculosis in a high HIV prevalence setting:A Prospective Study. PLoS Med. 2011;8:e1001061. - PMC - PubMed