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. 2019 Jun 30;3(Suppl):100-103.
doi: 10.1097/HS9.0000000000000236. eCollection 2019 Jun.

The diagnostic potential of the iron-regulatory hormone hepcidin

Andrew E Armitage  1 , Hal Drakesmith  1   2
Affiliations

The diagnostic potential of the iron-regulatory hormone hepcidin

Andrew E Armitage et al. Hemasphere. .
No abstract available

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Conflict of interest statement

Neither author has a conflict of interest to declare.

Figures

Figure 1
Figure 1
Potential utility of assessing hepcidin concentrations across clinical and physiological settings related to systemic iron homeostasis. Typical hepcidin concentrations vary considerably between diverse iron-related disorders and responses to distinct physiological challenges. Variation in hepcidin may aid differential diagnosis of distinct conditions with similar clinical presentations (here highlighted by fill color: yellow – iron deficiency / anemia / AI; blue – iron-loading disorders). Hepcidin may indicate the likely efficacy of response to iron interventions, and potentially whether oral or intravenous interventions should be preferred (∗when iron-overload is not indicated). In the future, hepcidin concentrations may guide the use of hepcidin antagonists (indicated by red outlines to boxes) or agonists (blue outlines) for disordered iron homeostasis. Note: in reality, there is likely considerable overlap in hepcidin concentrations between the conditions shown; the hierarchy shown is not intended to represent an exact order, but to give an indication of typical hepcidin concentrations (ie, typically raised vs normal vs suppressed) across the different conditions. AI = Anemia of Inflammation, CKD = Chronic Kidney Disease, HH = Hereditary Haemochromatosis – (HFE), caused by mutation in the HFE gene; (HJV/TfR2/HAMP), caused by mutations in Hemojuvelin, transferrin receptor 2 and hepcidin respectively, IBD = Inflammatory Bowel Disease, ICU = Intensive Care Unit, ID = Iron deficiency, IDA = Iron deficiency anemia, IRIDA = Iron-refractory iron deficiency anemia, LMIC = Low-/Middle-Income Country, NTDT = Non-transfusion dependent beta-Thalassemia, RA = Rheumatoid Arthritis, TDT = transfusion dependent beta-Thalassemia.
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