Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 2:9:800082.
doi: 10.3389/fsurg.2022.800082. eCollection 2022.

Spontaneous Ventilation Video-Assisted Thoracoscopic Surgery for Non-small-cell Lung Cancer Patients With Poor Lung Function: Short- and Long-Term Outcomes

Runchen Wang  1   2 , Qixia Wang  1   2 , Shunjun Jiang  1 , Chao Chen  1   2 , Jianqi Zheng  1 , Hui Liu  3 , Xueqing Liang  4 , Zhuxing Chen  1 , Haixuan Wang  1 , Zhuoxuan Guo  1 , Wenhua Liang  1 , Jianxing He  1   2 , Hengrui Liang  1 , Wei Wang  1
Affiliations

Spontaneous Ventilation Video-Assisted Thoracoscopic Surgery for Non-small-cell Lung Cancer Patients With Poor Lung Function: Short- and Long-Term Outcomes

Runchen Wang et al. Front Surg. .

Abstract

Objective: The goal of this study was to explore the feasibility and safety of spontaneous ventilation video-assisted thoracoscopic surgery (SV-VATS) for non-small-cell lung cancer (NSCLC) patients with poor lung function.

Methods: NSCLC patients with poor lung function who underwent SV-VATS or mechanical ventilation VATS (MV-VATS) from 2011 to 2018 were analyzed. 1:2 Propensity score matching (PSM) was applied, and the short- and long-term outcomes between the SV-VATS group and the MV-VATS group were compared.

Results: Anesthesia time (226.18 ± 64.89 min vs. 248.27 ± 76.07 min; P = 0.03), operative time (140.85 ± 76.07 min vs. 163.12 ± 69.37 min; P = 0.01), days of postoperative hospitalization (7.29 ± 3.35 days vs. 8.40 ± 7.89 days; P = 0.04), and days of chest tube use (4.15 ± 2.89 days vs. 5.15 ± 3.54 days; P = 0.01), the number of N1 station lymph node dissection (2.94 ± 3.24 vs. 4.34 ± 4.15; P = 0.005) and systemic immune-inflammation index (3855.43 ± 3618.61 vs. 2908.11 ± 2933.89; P = 0.04) were lower in SV-VATS group. Overall survival and disease-free survival were not significantly different between the two groups (OS: HR 0.66, 95% CI: 0.41-1.07, P = 0.09; DFS: HR 0.78, 95% CI: 0.42-1.45, P = 0.43).

Conclusions: Comparable short-term and long-term outcomes indicated that SV-VATS is a feasible and safe method and might be an alternative to MV-VATS when managing NSCLC patients with poor lung function.

Keywords: NIVATS; NSCLC; non-small lung cancer; poor lung function; spontaneous ventilation video-assisted thoracoscopic surgery.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of patient inclusion. NSCLC, non-small-cell lung cancer; SV-VATS, spontaneous ventilation video-assisted thoracoscopic surgery; MV-VATS, mechanical ventilation; BMI, body mass index; T, tumor; N, node; M, metastasis; ASA, american society of anesthesiologists.
Figure 2
Figure 2
(A) K-M survival curves for overall survival in patients underwent the SV-VATS and MV-VATS. (B) K-M survival curves for disease-free survival underwent the SV-VATS and MV-VATS. K-M, Kaplan–Meier; SV-VATS, spontaneous ventilation video-assisted thoracoscopic surgery; MV-VATS, mechanical ventilation.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Howington JA, Blum MG, Chang AC, Balekian AA, Murthy SC. Treatment of stage I and II non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. (2013) 143(5 Suppl):e278S–e313S. 10.1378/chest.12-2359 - DOI - PubMed
    1. Maniscalco P, Tamburini N, Quarantotto F, Grossi W, Garelli E, Cavallesco G. Long-term outcome for early stage thymoma: comparison between thoracoscopic and open approaches. Thorac Cardiovasc Surg. (2015) 63:201–5. 10.1055/s-0034-1396594 - DOI - PubMed
    1. Bendixen M, Jørgensen OD, Kronborg C, Andersen C, Licht PB. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol. (2016) 17:836–44. 10.1016/S1470-2045(16)00173-X - DOI - PubMed
    1. Yang CJ, Kumar A, Deng JZ, Raman V, Lui NS, D'Amico TA, et al. . A national analysis of short-term outcomes and long-term survival following thoracoscopic versus open lobectomy for clinical stage II non-small-cell lung cancer. Ann Surg. (2021) 273:595–605. 10.1097/SLA.0000000000003231 - DOI - PubMed
    1. Cui F, Xu K, Liang H, Liang W, Li J, Wang W, et al. . Spontaneous ventilation versus mechanical ventilation during video-assisted thoracoscopic surgery for spontaneous pneumothorax: a study protocol for multicenter randomized controlled trial. J Thorac Dis. (2020) 12:1570–81. 10.21037/jtd.2020.02.13 - DOI - PMC - PubMed