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. 2022 Mar 4:42:108014.
doi: 10.1016/j.dib.2022.108014. eCollection 2022 Jun.

Functional magnetic resonance imaging data for the association between polygenic risk scores for neuroticism and reward-punishment processing

Heekyeong Park  1   2 , Katherine L Forthman  1 , Rayus Kuplicki  1 , Teresa A Victor  1 ; Tulsa 1000 Investigators; Hung-Wen Yeh  1   3 , Wesley K Thompson  4 , Martin P Paulus  1
Affiliations

Functional magnetic resonance imaging data for the association between polygenic risk scores for neuroticism and reward-punishment processing

Heekyeong Park et al. Data Brief. .

Abstract

Neuroticism as a personality trait represents a heritable risk for psychiatric disorders. The polygenic risk score for neuroticism (N-PRS) is used to study genetic vulnerability to neuroticism. The current data present the association of the genetic risk for neuroticism to neural reward-punishment processing using functional magnetic resonance imaging. N-PRS was computed based on the individual's genotype information and a genome-wide association study on the UK Biobank data. While individuals performed a monetary incentive delay task, their neural activations for upcoming incentives (reward: gain, punishment: loss) were measured in blood oxygen level dependent (BOLD) signals during the delay phase. Multivariate ANCOVAs were used to analyze BOLD signals for finding the association between N-PRS and reward-punishment processing by the incentive valence (Related research article: H. Park, K.L. Forthman, R. Kuplicki, T.A. Victor, Tulsa 1000 Investigators, H.W. Yeh, W.K. Thompson, M.P. Paulus, Polygenic risk for neuroticism modulates response to gains and losses in the amygdala and caudate: evidence from a clinical cohort. J. Affect. Disord. 293 (2021) 124-132. https://doi.org/10.1016/j.jad.2021.06.016). These data can be used as reference data for future studies examining the role of the genetic propensity for personality traits in the context of psychiatric disorders.

Keywords: Genetics; Neuroticism; Polygenic risk score; Reward; fMRI.

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Conflict of interest statement

This work has been supported in part by The William K. Warren Foundation and the National Institute of General Medical Sciences Center Grant Award Number 1P20GM121312. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. MP is an advisor to Spring Care, Inc., a behavioral health startup, and he has received royalties for an article about methamphetamine in UpToDate.

Figures

Fig 1
Fig. 1
The workflow diagram of the study.
See this image and copyright information in PMC

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