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. 2022;28(4):349-360.
doi: 10.1007/s00761-022-01120-z. Epub 2022 Mar 15.

[Management of infections in patients with cancer]

[Article in German]
Annika Yanina Classen  1   2 , Michael Sandherr  3 , Jörg Janne Vehreschild  1   2   4 , Marie von Lilienfeld-Toal  5   6
Affiliations

[Management of infections in patients with cancer]

[Article in German]
Annika Yanina Classen et al. Onkologe (Berl). 2022.

Abstract
in English, German

Patients with cancer are at increased risk of infection due to disease-associated or therapy-induced immunosuppression. Taking into account globally increasing antimicrobial resistance rates and negative effects associated with antibiotic treatments, the effective, appropriate and guideline-conform use of anti-infectives must be promoted in this clinical setting. The application of antibacterial prophylaxis should be limited to high-risk patients. Infection diagnostics and therapeutic strategies differ depending on the extent of expected immunosuppression and the patient's individual risk factors.

Hämatologische und onkologische Patienten haben aufgrund der durch die Grunderkrankung bestehenden oder therapieassoziierten Immunsuppression oftmals ein deutlich erhöhtes Infektionsrisiko. Unter Berücksichtigung weltweit zunehmender antimikrobieller Resistenzen und negativer mit der Antibiotikatherapie assoziierter Effekte sollte der angemessene und leitliniengerechte Einsatz von Antiinfektiva auch in diesem Bereich gefördert werden. Die Indikation zur antibakteriellen Prophylaxe sollte streng gestellt werden. Die Infektionsdiagnostik sowie das therapeutische Management unterscheiden sich je nach Ausmaß der erwarteten Immunsuppression und nach vorliegenden patientenindividuellen Risikofaktoren.

Keywords: Antibiotic prophylaxis; Antibiotic stewardship; Drug resistance, microbial; Immunosuppression; Infections/risk factors.

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