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. 2021 Sep:27:100340.
doi: 10.1016/j.coisb.2021.05.001. Epub 2021 May 8.

Multiscale modeling in disease

Ashlee N Ford Versypt  1
Affiliations

Multiscale modeling in disease

Ashlee N Ford Versypt. Curr Opin Syst Biol. 2021 Sep.

Abstract

Multiscale computational modeling aims to connect the complex networks of effects at different length and/or time scales. For example, these networks often include intracellular molecular signaling, crosstalk, and other interactions between neighboring cell populations, and higher levels of emergent phenomena across different regions of tissues and among collections of tissues or organs interacting with each other in the whole body. Recent applications of multiscale modeling across intracellular, cellular, and/or tissue levels are highlighted here. These models incorporated the roles of biochemical and biomechanical modulation in processes that are implicated in the mechanisms of several diseases including fibrosis, joint and bone diseases, respiratory infectious diseases, and cancers.

Keywords: Agent-based modeling; Computational modeling; Extracellular matrix; Fibrosis; Inflammation; Metastasis; Multiscale modeling; Tissue growth; Tissue remodeling.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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References

    1. Friedman SL, Sheppard D, Duffield JS, Violette S: Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med 2013, 5:167sr1. - PubMed
    1. Goldman AW, Burmeister Y, Cesnulevicius K, Herbert M, Kane M, Lescheid D, McCaffrey T, Schultz M, Seilheimer B, Smit A, et al.: Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient’s autoregulatory capacity? Front Physiol 2015, 6:225. - PMC - PubMed
    1. Karsdal MA, Manon-Jensen T, Genovese F, Kristensen JH, Nielsen MJ, Sand JM, Hansen NU, Bay-Jensen AC, Bager CL, Krag A, et al.: Novel insights into the function and dynamics of extracellular matrix in liver fibrosis. Am J Physiol Gastrointest Liver Physiol 2015, 308:G807–G830. - PMC - PubMed
    1. Viola H, Chang J, Grunwell JR, Hecker L, Tirouvanziam R, Grotberg JB, Takayama S: Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair. APL Bioeng 2019, 3, 041503. - PMC - PubMed
    1. Cappuccio A, Tieri P, Castiglione F: Multiscale modelling in immunology: a review. Briefings Bioinf 2016, 17:408–418. - PubMed

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