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Comment
. 2022 Apr 1;50(4):e402-e403.
doi: 10.1097/CCM.0000000000005418.

Early Vasopressor Initiation Increases Mortality in Patients With Septic Shock: Less Intensive Intervention or More Critically Ill Patients?

Heyan Wang  1 , Hangyong He  2 , Feng Shen  3
Affiliations
Comment

Early Vasopressor Initiation Increases Mortality in Patients With Septic Shock: Less Intensive Intervention or More Critically Ill Patients?

Heyan Wang et al. Crit Care Med. .
No abstract available

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Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

Comment in

  • The authors reply.
    Yeo HJ, Cho WH. Yeo HJ, et al. Crit Care Med. 2022 Apr 1;50(4):e403-e404. doi: 10.1097/CCM.0000000000005455. Crit Care Med. 2022. PMID: 35311789 No abstract available.

Comment on

References

    1. Yeo HJ, Lee YS, Kim TH, et al.; Korean Sepsis Alliance (KSA) Investigators: Vasopressor Initiation Within 1 Hour of Fluid Loading Is Associated With Increased Mortality in Septic Shock Patients: Analysis of National Registry Data. Crit Care Med 2022; 50:e351–e360
    1. Permpikul C, Tongyoo S, Viarasilpa T, et al.: Early use of norepinephrine in septic shock resuscitation (CENSER). A randomized trial. Am J Respir Crit Care Med 2019; 199:1097–1105
    1. Bai X, Yu W, Ji W, et al.: Early versus delayed administration of norepinephrine in patients with septic shock. Crit Care 2014; 18:532
    1. Ospina-Tascón GA, Hernandez G, Alvarez I, et al.: Effects of very early start of norepinephrine in patients with septic shock: A propensity score-based analysis. Crit Care 2020; 24:52
    1. Evans L, Rhodes A, Alhazzani W, et al.: Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021. Crit Care Med 2021; 49:e1063–e1143

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