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. 2022 May;87(5):e13531.
doi: 10.1111/aji.13531. Epub 2022 Mar 21.

Longitudinal changes in serum immune markers during normal pregnancy in a North-Indian population

Khushboo Kaushal  1 , Ayushi  1 , Nikhil Sharma  1 , Nitya Wadhwa  1 , Sumit Misra  1 , Shinjini Bhatnagar  1 , Bapu Koundinya Desiraju  1 , Ramachandran Thiruvengadam  1 , Shailaja Sopory  1 ; GARBH-Ini study group  1
Affiliations

Longitudinal changes in serum immune markers during normal pregnancy in a North-Indian population

Khushboo Kaushal et al. Am J Reprod Immunol. 2022 May.

Erratum in

Abstract

Problem: The objective of this study was to examine levels of cytokines across normal term pregnancy in an Indian population. Additionally we have also explored for possible associations between inflammatory markers and fetal growth parameters.

Method of study: A multiplex panel of 24 analytes was used to examine levels of inflammatory markers in maternal serum at three time points during pregnancy and in cord blood from women with no reported comorbidities who delivered a singleton live baby at term (N = 23), enrolled in the GARBH-Ini pregnancy cohort. Linear mixed models were applied to construct longitudinal cytokine trajectories with gestational age. Pearson correlation was used to calculate intra-visit correlation between cytokines. Principal component analysis (PCA) was performed to examine cytokine combinations prevalent across pregnancy, and their association with fetal growth parameters was determined by multivariable regression.

Results: Significant increase in sFLT-1, Flt3L, PLGF, IL-4, and IL-18 and a decrease in VCAM-1 concentrations was seen across pregnancy. The cytokine concentrations in cord blood differed substantially as compared to maternal levels across gestation. Some cytokines were closely correlated with each other in distinct patterns across pregnancy. Gestational age specific combination of cytokines were seen to be associated with different fetal growth parameters.

Conclusions: This study for the first time provides reference concentrations for the longitudinal expression of immune markers across pregnancy in an Indian population providing a much needed baseline to compare with pregnancies leading to adverse outcomes. Growth factors showed maximum longitudinal variation with gestational age and strong correlations were identified between various cytokines at all time points across pregnancy.

Keywords: India; cytokines; fetal biometry; longitudinal; pregnancy; serum.

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References

REFERENCES

    1. Wang W, Sung N, Gilman-Sachs A, Kwak-Kim J. T helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1/Th2/Th9/Th17/Th22/Tfh cells. Front Immunol. 2020;11:2025. https://doi.org/10.3389/fimmu.2020.02025
    1. Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol. 2010;63(6):601-10. https://doi.org/10.1111/j.1600-0897.2010.00852.x
    1. Dekel N, Gnainsky Y, Granot I, Racicot K, Mor G. The role of inflammation for a successful implantation. Am J Reprod Immunol. 2014;72(2):141-7. https://doi.org/10.1111/aji.12266
    1. Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 2010;63(6):425-33. https://doi.org/10.1111/j.1600-0897.2010.00836.x
    1. Mor G, Cardenas I, Abrahams V, Guller S. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci. 2011;1221:80-7. https://doi.org/10.1111/j.1749-6632.2010.05938.x

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