Mechanisms of interactions between bacteria and bacteriophage mediate by quorum sensing systems

Yuxin Wang¹, Jianjun Dai^{1

2}, Xuhang Wang¹, Yang Wang³, Fang Tang⁴

Affiliations

¹ MOE Joint International Research Laboratory of Animal Health and Food Safety, Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
² School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
³ College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
⁴ MOE Joint International Research Laboratory of Animal Health and Food Safety, Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China. tfalice@126.com.

PMID: 35312824
DOI: 10.1007/s00253-022-11866-6

Review

Mechanisms of interactions between bacteria and bacteriophage mediate by quorum sensing systems

Yuxin Wang et al. Appl Microbiol Biotechnol. 2022 Apr.

. 2022 Apr;106(7):2299-2310.

doi: 10.1007/s00253-022-11866-6. Epub 2022 Mar 21.

Authors

Yuxin Wang¹, Jianjun Dai^{1

2}, Xuhang Wang¹, Yang Wang³, Fang Tang⁴

Affiliations

¹ MOE Joint International Research Laboratory of Animal Health and Food Safety, Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
² School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
³ College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
⁴ MOE Joint International Research Laboratory of Animal Health and Food Safety, Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China. tfalice@126.com.

PMID: 35312824
DOI: 10.1007/s00253-022-11866-6

Abstract

Bacteriophage (phage) and their host bacteria coevolve with each other over time. Quorum sensing (QS) systems play an important role in the interaction between bacteria and phage. In this review paper, we summarized the function of QS systems in bacterial biofilm formation, phage adsorption, lysis-lysogeny conversion of phage, coevolution of bacteria and phage, and information exchanges in phage, which may provide reference to future research on alternative control strategies for antibiotic-resistant and biofilm-forming pathogens by phage. KEY POINTS: • Quorum sensing (QS) systems influence bacteria-phage interaction. • QS systems cause phage adsorption and evolution and lysis-lysogeny conversion. • QS systems participate in biofilm formation and co-evolution with phage of bacteria.

Keywords: Bacteria-phage; Interactions; Mechanisms; Quorum sensing systems.

PubMed Disclaimer

Cited by

Re-Emergence of Bacteriophages and Their Products as Antibacterial Agents: An Overview.
Kalia VC, Patel SKS, Gong C, Lee JK. Kalia VC, et al. Int J Mol Sci. 2025 Feb 19;26(4):1755. doi: 10.3390/ijms26041755. Int J Mol Sci. 2025. PMID: 40004222 Free PMC article. Review.
Investigation into scalable and efficient enterotoxigenic Escherichia coli bacteriophage production.
Wiebe KG, Cook BWM, Lightly TJ, Court DA, Theriault SS. Wiebe KG, et al. Sci Rep. 2024 Feb 13;14(1):3618. doi: 10.1038/s41598-024-53276-w. Sci Rep. 2024. PMID: 38351153 Free PMC article.
Quorum sensing gene lasR promotes phage vB_Pae_PLY infection in Pseudomonas aeruginosa.
Liu Y, Yao Z, Mao Z, Tang M, Chen H, Qian C, Zeng W, Zhou T, Wu Q. Liu Y, et al. BMC Microbiol. 2024 Jun 10;24(1):207. doi: 10.1186/s12866-024-03349-7. BMC Microbiol. 2024. PMID: 38858621 Free PMC article.
The Role of Quorum Sensing in Phage Lifecycle Decision: A Switch Between Lytic and Lysogenic Pathways.
Shang J, Wang K, Zhou Q, Wei Y. Shang J, et al. Viruses. 2025 Feb 26;17(3):317. doi: 10.3390/v17030317. Viruses. 2025. PMID: 40143247 Free PMC article. Review.
The Burden of Survivors: How Can Phage Infection Impact Non-Infected Bacteria?
Letarov AV, Letarova MA. Letarov AV, et al. Int J Mol Sci. 2023 Feb 1;24(3):2733. doi: 10.3390/ijms24032733. Int J Mol Sci. 2023. PMID: 36769055 Free PMC article. Review.

See all "Cited by" articles

References

1. Abisado RG, Benomar S, Klaus JR, Dandekar AA, Chandler JR (2018) Bacterial quorum sensing and microbial community interactions. mBio 9(3):e02331–e02317. https://doi.org/10.1128/mBio.02331-17 - DOI - PubMed - PMC
1. Agarwal B, Karthikeyan R, Gayathri P, Rameshbabu B, Ahmed G, Jagannadham MV (2018) Studies on the mechanism of multidrug resistance of Acinetobacter baumannii by proteomic analysis of the outer membrane vesicles of the bacterium. J Proteins Proteomics 10. https://doi.org/10.1007/s42485-018-0001-4
1. Alexander B, Benoit Q, Alexei S, S Dusko E (2005) Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin. Microbiol 151:2551-2561. https://doi.org/10.1099/mic.0.28048-0
1. Ambroa A, Blasco L, Lopez-Causape C, Trastoy R, Fernandez-Garcia L, Bleriot I, Ponce-Alonso M, Pacios O, Lopez M, Canton R, Kidd TJ, Bou G, Oliver A, Tomas M (2020) Temperate bacteriophages (prophages) in pseudomonas aeruginosa isolates belonging to the international cystic fibrosis clone (CC274). Front Microbiol 11:556706. https://doi.org/10.3389/fmicb.2020.556706 - DOI - PubMed - PMC
1. Ana O, Sousa JC, Silva AC, Melo L, Sanna S (2018) Chestnut honey and bacteriophage application to control pseudomonas aeruginosa and escherichia coli biofilms: evaluation in anex vivoWound Model. Front Microbiol 9:1725–1738. https://doi.org/10.3389/fmicb.2018.01725 - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Mechanisms of interactions between bacteria and bacteriophage mediate by quorum sensing systems

Affiliations

Mechanisms of interactions between bacteria and bacteriophage mediate by quorum sensing systems

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources