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. 2022 Mar 22;20(1):94.
doi: 10.1186/s12916-022-02289-1.

The influence of childhood asthma on adult height: evidence from the UK Biobank

Wenwen Chen  1   2   3 , Huazhen Yang  2   3 , Can Hou  2   3 , Yajing Sun  2   3 , Yanan Shang  2   3 , Yu Zeng  2   3 , Yao Hu  2   3 , Yuanyuan Qu  2   3 , Jianwei Zhu  4 , Fang Fang  5 , Donghao Lu  2   5   6 , Huan Song  7   8   9
Affiliations

The influence of childhood asthma on adult height: evidence from the UK Biobank

Wenwen Chen et al. BMC Med. .

Abstract

Background: To elucidate the influence of childhood asthma on adult height after consideration of genetic heterogeneity in height.

Methods: Based on the UK Biobank, we conducted a matched cohort study, including 13,602 European individuals with asthma diagnosed before 18 years old and 136,008 matched unexposed individuals without such an experience. Ascertainment of asthma was based on self-reported data (97.6%) or clinical diagnosis in healthcare registers (2.4%). We studied three height outcomes, including (1) the attained adult height (in centimeters), (2) the height deviation measured as the difference between a person's rank of genetically determined height (based on generated polygenetic risk score) and their rank of attained adult height in the study population (deviation in % of height order after standardization), and (3) the presence of height deficit comparing genetically determined and attained height (yes or no). We applied linear mixed-effect models to assess the associations of asthma diagnosed at different ages with attained adult height and height deviation, and conditional logistic regression models to estimate the associations of asthma with the risk of height deficit.

Results: 40.07% (59,944/149,610) of the study participants were born before 1950, and most of them were men (57.65%). After controlling for multiple covariates, childhood asthma was associated with shorter attained adult height, irrespective of age at asthma diagnosis. However, in the analysis of height deviation (deviation in %), we observed the greatest height deviation among individuals with asthma diagnosed before 4 years of age (- 2.57 [95% CI - 4.14 to - 1.00] and - 2.80 [95% CI - 4.06 to - 1.54] for the age of ≤ 2 and 3-4 years, respectively). The magnitude of height deviation in relation to asthma declined thereafter and became null after age 6. Similarly, there was a statistically significant height deficit in relation to an asthma diagnosis at ages ≤ 2 and 3-4 (odds ratios = 1.21, 95% CI 1.04 to 1.40, and 1.15, 95% CI 1.02 to 1.29) but not thereafter. The result pattern was similar when separately analyzing asthma with or without inhaled glucocorticoid (ICS) use, despite that the estimates were consistently stronger among asthma individuals who used ICS.

Conclusions: Our results suggest a notable association of childhood asthma, primarily asthma diagnosed at an early age, with adult height, after consideration of genetic heterogeneity in height and use of ICS. This finding highlights the need for surveillance on the growth problems among children with asthma.

Keywords: Adult height; Childhood asthma; Genetic heterogeneity.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study flowchart. aAssessment of asthma is based on the ICD-10 codes (J45) recorded in the first occurrences data field
See this image and copyright information in PMC

References

    1. Collaborators GDaIIaP Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. Lancet (London, England) 2018;392(10159):1789–1858. doi: 10.1016/S0140-6736(18)32279-7. - DOI - PMC - PubMed
    1. Centers for Disease Control. Most recent national asthma data (2019); Available from: https://www.cdc.gov/asthma/most_recent_national_asthma_data.htm. Accessed 9 Sept 2021.
    1. Wolthers OD. Growth problems in children with asthma. Horm Res. 2002;57(Suppl 2):83–87. - PubMed
    1. Baum WF, Schneyer U, Lantzsch AM, Kloditz E. Delay of growth and development in children with bronchial asthma, atopic dermatitis and allergic rhinitis. Exper Clin Endocrinol Diab. 2002;110(2):53–59. doi: 10.1055/s-2002-23486. - DOI - PubMed
    1. Khan DA. Exercise-induced bronchoconstriction: burden and prevalence. Allergy Asthma Proc. 2012;33(1):1–6. doi: 10.2500/aap.2012.33.3507. - DOI - PubMed

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