Comment
doi: 10.1038/s41591-022-01743-0.
Polygenic embryo testing: understated ethics, unclear utility
Affiliations
- PMID: 35314818
- PMCID: PMC9208380
- DOI: 10.1038/s41591-022-01743-0
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Comment
Polygenic embryo testing: understated ethics, unclear utility
Nat Med.
2022 Mar.
Abstract
New technologies are expanding the reach and accessibility of pre-implantation genetic testing of human embryos. But what these advances can deliver is still unclear and a frank assessment of their profound ethical implications is crucial.
Conflict of interest statement
Comment on
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Whole-genome risk prediction of common diseases in human preimplantation embryos.Nat Med. 2022 Mar;28(3):513-516. doi: 10.1038/s41591-022-01735-0. Epub 2022 Mar 21. Nat Med. 2022. PMID: 35314819 Free PMC article.
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References
-
- Kumar A et al. Nat. Med [insert link/rest of citation] (2022).
-
- Takahashi S, Johnston J & Patrizio P Genet. Med 21, 1038–1040 (2019). - PubMed
-
- Sandel MJL Phil. & Culture 3, 153–158 (2009).
-
- Bayefsky M & Jennings B Regulating Preimplantation Genetic Diagnosis in the United States: The Limits of Unlimited Selection (Springer, 2015).
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