CAR T cells reach clinical milestone in prostate cancer

Nicholas P Tschernia¹, Scott M Norberg¹, James L Gulley²

Affiliations

¹ Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA.
² Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA. gulleyj@mail.nih.gov.

PMID: 35314844
DOI: 10.1038/s41591-022-01742-1

Comment

CAR T cells reach clinical milestone in prostate cancer

Nicholas P Tschernia et al. Nat Med. 2022 Apr.

. 2022 Apr;28(4):635-636.

doi: 10.1038/s41591-022-01742-1.

Authors

Nicholas P Tschernia¹, Scott M Norberg¹, James L Gulley²

Affiliations

¹ Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA.
² Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA. gulleyj@mail.nih.gov.

PMID: 35314844
DOI: 10.1038/s41591-022-01742-1

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PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial.
Narayan V, Barber-Rotenberg JS, Jung IY, Lacey SF, Rech AJ, Davis MM, Hwang WT, Lal P, Carpenter EL, Maude SL, Plesa G, Vapiwala N, Chew A, Moniak M, Sebro RA, Farwell MD, Marshall A, Gilmore J, Lledo L, Dengel K, Church SE, Hether TD, Xu J, Gohil M, Buckingham TH, Yee SS, Gonzalez VE, Kulikovskaya I, Chen F, Tian L, Tien K, Gladney W, Nobles CL, Raymond HE; Prostate Cancer Cellular Therapy Program Investigators; Hexner EO, Siegel DL, Bushman FD, June CH, Fraietta JA, Haas NB. Narayan V, et al. Nat Med. 2022 Apr;28(4):724-734. doi: 10.1038/s41591-022-01726-1. Epub 2022 Mar 21. Nat Med. 2022. PMID: 35314843 Free PMC article. Clinical Trial.

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References

1. Narayan, V. et al. Nat. Med. https://doi.org/10.1038/s41591-022-01726-1 (2022). - DOI - PubMed
1. Rosa, K. OncLive https://www.onclive.com/view/p-psma-101-elicits-encouraging-responses-in... (September 2021).
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CAR T cells reach clinical milestone in prostate cancer

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