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. 2022 Aug 24;75(1):e865-e868.
doi: 10.1093/cid/ciac223.

Severe Acute Respiratory Syndrome Coronavirus 2 Adaptive Immunity in Nursing Home Residents Following a Third Dose of the Comirnaty Coronavirus Disease 2019 Vaccine

Estela Giménez  1 , Eliseo Albert  1 , Joao Zulaica  2 , Ignacio Torres  1 , Luciana Rusu  2 , Alicia Rodríguez Moreno  2 , Javier S Burgos  3 , Salvador Peiró  4 , Dolores Salas  4   5 , Hermelinda Vanaclocha  5 , Ramón Limón  6 , María Jesús Alcaraz  1 , José Sánchez-Payá  7   8 , Javier Díez-Domingo  4 , Iñaki Comas  9   10 , Fernando Gonzáles-Candelas  2   10 , Ron Geller  2 , David Navarro  1   11 ; Valencian Vaccine Research Program (ProVaVac) Study Group
Collaborators, Affiliations

Severe Acute Respiratory Syndrome Coronavirus 2 Adaptive Immunity in Nursing Home Residents Following a Third Dose of the Comirnaty Coronavirus Disease 2019 Vaccine

Estela Giménez et al. Clin Infect Dis. .

Abstract

A third Comirnaty vaccine dose increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain antibody levels (median, 93-fold) and neutralizing antibody titers against Wuhan-Hu-1 (median, 57-fold), Beta (me 22-fold), Delta, (median, 43-fold), and Omicron (median, 8-fold) variants, but had less impact on S-reactive T-cell immunity in nursing home residents.

Keywords: Comirnaty COVID-19 vaccine third dose; SARS-CoV-2-S T cells; SARS-CoV-2-S antibodies; neutralizing antibodies; nursing home residents.

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