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. 2022 Mar 14;93(1):e2022018.
doi: 10.23750/abm.v93i1.12224.

SARS-CoV-2 Variants of Concern Increased Transmission and Decrease Vaccine Efficacy in the COVID-19 Pandemic in Palembang Indonesia

Ahmad Ghiffari  1 , Chairil Anwar  2 , Hamzah Hasyim  3 , Iskhaq Iskandar  4 , Muhammad Totong Kamaluddin  5
Affiliations

SARS-CoV-2 Variants of Concern Increased Transmission and Decrease Vaccine Efficacy in the COVID-19 Pandemic in Palembang Indonesia

Ahmad Ghiffari et al. Acta Biomed. .

Abstract

Background and aim: The number of COVID-19 cases surging despite the large scale of health promotion campaigns. This study aimed to find disease transmissibility and affected vaccine efficacy associated with the mutation of the SARS-CoV-2 variant of concern.

Methods: The study was a descriptive temporal survey design with secondary ecological data: the whole-genome sequence (WGS) from the Global Initiative on Sharing Avian Influenza (GISAID) and COVID-19 data from the Palembang City Health Office website. Bioinformatics software was used to detect mutations.

Results: Palembang submitted 43 whole genome sequences, 13 of which were Pangoline sequences classifications.

Conclusions: The two concern variations, Alpha and Delta, were associated with increased transmissions and decreased vaccination efficacy using temporal analysis. Regulations governing the relaxation of mobility restrictions should be based on high rates of testing and tracing, and universal vaccination programs should require that all received two doses of any vaccines as fast as possible.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

Figures

Figure 1.
Figure 1.
The Number of COVID-19 events per day, Earliest Detection 0f SARS-CoV-2 the Delta Variant of Concern was January 8, 2021, and The National Vaccine Campaign has been Commenced on January 14, 2021.
Figure 2.
Figure 2.
Single Letter Codes of Amino Acid Changes at Specified Position and Proposed Effect of Increase Transmission, shown in Black Column (a) 501 Mutation N to Y; (b) 614 Mutation D to G or R; (c) 681 Mutation P to H or R.
Figure 3.
Figure 3.
Single Letter Codes of Amino Acid Changes at Specified Position and Proposed Effect of Decreased Neutralization, shown in red column (a) 439 mutation N to K; (b) 452 mutation L to R; (c) 484 mutation E to K or Q.
See this image and copyright information in PMC

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Publication types

Supplementary concepts