Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jun;27(5-6):311-321.
doi: 10.1007/s10495-022-01722-3. Epub 2022 Mar 22.

The role of lncRNA OIP5-AS1 in cancer development and progression

Cheng Zheng #  1 , Man Chu #  2 , Qiuli Chen  3   4 , Cheng Chen  2 , Zhi-Wei Wang  5 , Xiao Chen  6   7
Affiliations
Review

The role of lncRNA OIP5-AS1 in cancer development and progression

Cheng Zheng et al. Apoptosis. 2022 Jun.

Abstract

OIP5-AS1, a conserved lncRNA, has been reported to be involved in several biological and pathological processes, including oncogenesis. OIP5-AS1 exerts its oncogenic or antitumor functions via regulation of different miRNAs in various cancer types. In this review, we describe the dysregulation of OIP5-AS1 expression in a variety of human cancers. Moreover, we discuss the multiple functions of OIP5-AS1 in cancer, including in proliferation, apoptosis, autophagy, ferroptosis, cell cycle, migration, metastasis, invasion, epithelial to mesenchymal transition, angiogenesis, cancer stem cells and drug resistance. Furthermore, we provide a future perspective for OIP5-AS1 research. We conclude that targeting OIP5-AS1 might be a promising cancer therapy approach.

Keywords: Cancer; OIP5-AS1; Oncogene; Therapy; miRNAs.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Winkle M, El-Daly SM, Fabbri M, Calin GA (2021) Noncoding RNA therapeutics - challenges and potential solutions. Nat Rev Drug Discov 20:629–651 - PubMed - PMC - DOI
    1. Liu SJ, Dang HX, Lim DA, Feng FY, Maher CA (2021) Long noncoding RNAs in cancer metastasis. Nat Rev Cancer 21:446–460 - PubMed - PMC - DOI
    1. Wahlestedt C (2013) Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov 12:433–446 - PubMed - DOI
    1. Ghafouri-Fard S, Dashti S, Farsi M, Hussen BM, Taheri M (2021) A review on the role of oncogenic lncRNA OIP5-AS1 in human malignancies. Biomed Pharmacother 137:111366 - PubMed - DOI
    1. Sun WL, Kang T, Wang YY et al (2019) Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410. Biosci Rep 39(1):395

MeSH terms

LinkOut - more resources