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. 2022 Jun;76(3):645-653.
doi: 10.1007/s11418-022-01613-6. Epub 2022 Mar 22.

Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium

Ai Ogasawara  1 , Ryo Noguchi  1 , Takuya Shigi  1 , Alfarius Eko Nugroho  1 , Yusuke Hirasawa  1 , Toshio Kaneda  1 , Takahiro Tougan  2 , Toshihiro Horii  3 , A Hamid A Hadi  4 , Hiroshi Morita  5
Affiliations

Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium

Ai Ogasawara et al. J Nat Med. 2022 Jun.

Abstract

Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A-E (1-5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A-F (1-6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain.

Keywords: Antimalarial activity; Caloforines A–G; Calophyllum scriblitifolium; Coumarin; Pyranocoumarin.

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Figures

Fig. 1
Fig. 1
Structures of 1–7
Fig. 2
Fig. 2
Selected 2D NMR correlations of 1
Fig. 3
Fig. 3
Selected 2D NMR correlations of 2
Fig. 4
Fig. 4
Selected 2D NMR correlations of 3, 4 and 5
Fig. 5
Fig. 5
Stable conformers of 1 and 3
Fig. 6
Fig. 6
Experimental and calculated CD spectra of 1–5
Fig. 7
Fig. 7
Selected 2D NMR correlations of 6 and 7
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References

    1. Wiesner J, Ortmann R, Jomaa H, Schlitzer M. New antimalarial drugs. Angew Chem Int Ed. 2003;42:5274–5293. doi: 10.1002/anie.200200569. - DOI - PubMed
    1. Tang Y, Nugroho AE, Hirasawa Y, Tougan T, Horii T, Hadi AHA, Morita H. Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia. J Nat Med. 2019;73:533–540. doi: 10.1007/s11418-019-01297-5. - DOI - PubMed
    1. Amelia P, Nugroho AE, Hirasawa Y, Kaneda T, Tougan T, Horii T, Morita H. Indole alkaloids from Tabernaemontana macrocarpa Jack. J Nat Med. 2019;73:820–825. doi: 10.1007/s11418-019-01317-4. - DOI - PubMed
    1. Nugroho AE, Hirasawa Y, Kaneda T, Shirota O, Matsuno M, Mizukami H, Morita H. Triterpenoids from Walsura trichostemon. J Nat Med. 2021;75:415–422. doi: 10.1007/s11418-021-01483-4. - DOI - PubMed
    1. Nugroho AE, Ono Y, Jin E, Hirasawa Y, Kaneda T, Rahman A, Kusumawati I, Tougan T, Horii T, Zaini NC, Morita H. Bisindole alkaloids from Voacanga grandifolia leaves. J Nat Med. 2021;75:408–414. doi: 10.1007/s11418-020-01475-w. - DOI - PubMed

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