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. 2022 Sep;16(3):755-762.
doi: 10.1007/s12105-022-01441-w. Epub 2022 Mar 22.

Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World

Rafael Ferreira E Costa  1 , Marina Luiza Baião Leão  1 , Maria Sissa Pereira Sant'Ana  1 , Ricardo Alves Mesquita  1 , Ricardo Santiago Gomez  1 , Alan Roger Santos-Silva  2 , Syed Ali Khurram  3 , Artysha Tailor  3 , Ciska-Mari Schouwstra  4 , Liam Robinson  4 , Willie F P van Heerden  4 , Ramiro Alejandro Tomasi  5 , Romina Gorrino  5 , Ruth Salomé Ferreyra de Prato  5 , Adalberto Mosqueda Taylor  6 , José Manuel Aguirre Urizar  7 , Irene Lafuente Ibañez de Mendoza  7 , Raghu Radhakrishnan  8 , Chetana Chandrashekar  8 , Siu-Wai Choi  9 , Peter Thomson  9 , Hélder Antônio Rebelo Pontes  10 , Felipe Paiva Fonseca  11   12   13
Affiliations

Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World

Rafael Ferreira E Costa et al. Head Neck Pathol. 2022 Sep.

Erratum in

  • Author Correction: Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World.
    Ferreira E Costa R, Leão MLB, Sant'Ana MSP, Mesquita RA, Gomez RS, Santos-Silva AR, Khurram SA, Tailor A, Schouwstra CM, Robinson L, van Heerden WFP, Tomasi RA, Gorrino R, de Prato RSF, Taylor AM, Urizar JMA, de Mendoza ILI, Radhakrishnan R, Chandrashekar C, Choi SW, Thomson P, Pontes HAR, Fonseca FP. Ferreira E Costa R, et al. Head Neck Pathol. 2022 Dec;16(4):1263. doi: 10.1007/s12105-022-01503-z. Head Neck Pathol. 2022. PMID: 36239868 Free PMC article. No abstract available.

Abstract

Oral squamous cell carcinoma (OSCC) commonly affects older patients; however, several studies have documented an increase in its incidence among younger patients. Therefore, it is important to investigate if this trend is also found in different geographic regions. The pathology files of diagnostic and therapeutic institutions from different parts of the globe were searched for OSCC cases diagnosed from 1998 to 2018. Data regarding the sex, age, and tumor location of all cases, as well as the histologic grade and history of exposure to risk habits of cases diagnosed as OSCC in young patients (≤ 40 years of age) were obtained. The Chi-square test was used to determine any increasing trend. A total of 10,727 OSCC cases were identified, of which 626 cases affected young patients (5.8%). Manipal institution (India) showed the highest number of young patients (13.2%). Males were the most affected in both age groups, with the tongue and floor of the mouth being the most affected subsites. OSCC in young individuals were usually graded as well or moderately differentiated. Only 0.9% of the cases occurred in young patients without a reported risk habit. There was no increasing trend in the institutions and the period investigated (p > 0.05), but a decreasing trend was observed in Hong Kong and the sample as a whole (p < 0.001). In conclusion there was no increase of OSCC in young patients in the institutions investigated and young white females not exposed to any known risk factor represented a rare group of patients affected by OSCC.

Keywords: Epidemiology; Incidence; Oral cancer; Oral squamous cell carcinoma; Prevalence; Young patients.

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Conflict of interest statement

No conflict of interest to disclose.

Figures

Fig. 1
Fig. 1
Distribution of OSCC in young patients from 1998 to 2018 in different parts of the world for every five years. A Belo Horizonte (Brazil). B Cordoba (Argentina). C Mexico City (Mexico). D Pretoria (South Africa). E Sheffield (UK). F Bilbao (Spain). G Hong Kong (China) and H Manipal (India). a, b, c Statistically significant difference. a between 2003/2008 and 2009/2013. b between 2003/2008 and 2014/2018. c 2009/2013 and 2014/2018
See this image and copyright information in PMC

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