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. 2022 May:134:102187.
doi: 10.1016/j.tube.2022.102187. Epub 2022 Mar 17.

Gene expression in TB disease measured from the periphery is different from the site of infection

Dawda Jobe  1 , Fatoumatta Darboe  2 , Caleb N Muefong  1 , Amadou Barry  1 , Edward Goreh Coker  1 , Nuredin Mohammed  1 , Alhaji Jobe  1 , Monica Me Davies  1 , Babou Faye  1 , Rohey Jallow  1 , Simon Donkor  1 , Sunkaru Touray  3 , Olumuyiwa Owolabi  1 , Jayne S Sutherland  1
Affiliations

Gene expression in TB disease measured from the periphery is different from the site of infection

Dawda Jobe et al. Tuberculosis (Edinb). 2022 May.
No abstract available

Keywords: Biomarker; Bronchoalveolar lavage; Diagnostic; Whole blood; mRNA.

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Figures

Fig. 1
Fig. 1
Differential gene expression in whole blood and BALF and at the different stages of TB disease. A-D): Differences in fold change expression for genes of interest relative to housekeeping gene between whole blood and BAL, shown in Log10. Lines represent medians, dots represent individual responses. Only significant p-values (p < 0.05) are shown, p-values calculated using Kruskal-Wallis and Dunn's multiple comparison test. E-H): Correlation of fold change expression for genes of interest relative to housekeeping gene between whole blood and BAL, shown in Log10. I-L): Differences in fold change expression for genes of interest relative to housekeeping gene between pre and post treatment samples from cases and healthy controls shown in Log10. Lines represent medians, dots represent individual responses. Only significant p-values (p < 0.05) are shown, p-values calculated using Kruskal-Wallis and Dunn's multiple comparison test.
See this image and copyright information in PMC

References

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