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Review
. 2022 Mar 4:12:848376.
doi: 10.3389/fonc.2022.848376. eCollection 2022.

The Interaction Between Non-Coding RNAs and Calcium Binding Proteins

Soudeh Ghafouri-Fard  1 , Jamal Majidpoor  2 , Hamed Shoorei  3 , Bashdar Mahmud Hussen  4   5 , Hazha Hadayat Jamal  6 , Aria Baniahmad  7 , Mohammad Taheri  7   8 , Majid Mokhtari  9
Affiliations
Review

The Interaction Between Non-Coding RNAs and Calcium Binding Proteins

Soudeh Ghafouri-Fard et al. Front Oncol. .

Abstract

Calcium binding proteins (CBP) are a group of proteins mediating the effects of calcium on cellular functions. These proteins can regulate calcium levels inside the cells and contribute in several cellular functions through transporting this ion across cell membranes or decoding related signals. Recent studies have shown that several non-coding RNAs interact with CBPs to affect their expression or activity. The interactions between these transcripts and CBPs have implications in the pathoetiology of human disorders, including both neoplastic and non-neoplastic conditions. In the current review, we describe the interactions between three classes of non-coding RNAs (long non-coding RNAs, circular RNAs, and microRNAs) and a number of CBPs, particularly CAB39, S100A1, S100A4, S100A7 and S100P. This kind of interaction has been verified in different pathological contexts such as drug-induced cardiotoxicity, osteoblasts cytotoxicity, acute lung injury, myocardial ischemia/reperfusion injury, proliferative diabetic retinopathy, glomerulonephritis, as well as a wide array of neoplastic conditions.

Keywords: calcium binding protein; circRNA; lncRNA; miRNA; non-coding RNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The connection between CAB39 and miRNAs, as well as their role in human diseases. Inhibition of miRNA has resulted in increased CAB39 levels and increased activity of AMPK pathway. Cab39 has therefore been found as a miRNAs target, and these miRNAs modulate cardiotoxicity, osteoblasts, cytotoxicity, acute lung damage, chemoresistance, senescence, and cancer development through this RNA.
Figure 2
Figure 2
Interaction between CBPs (CAB39 and S100A4) and lncRNAs/circRNAs with their contribution in human disorders.
Figure 3
Figure 3
The interaction of CBPs (S100A4, S100A7, S100A16, S100A9) with miRNAs.
See this image and copyright information in PMC

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