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Review
. 2022 Mar 4:2022:7862709.
doi: 10.1155/2022/7862709. eCollection 2022.

Associations between AGT M235T Polymorphism and Cancer: An Updated Meta-Analysis

Junyan Kou  1 , Jing Huang  1
Affiliations
Review

Associations between AGT M235T Polymorphism and Cancer: An Updated Meta-Analysis

Junyan Kou et al. J Renin Angiotensin Aldosterone Syst. .

Abstract

We assessed the relationship between AGT gene M235T polymorphism and the susceptibility to cancer by performing an updated meta-analysis. This study retrospectively searched related articles in the electronic databases. Afterwards, we determined combined odds ratios (ORs) and related 95% confidence intervals (CIs) by the fixed- or random-effects model. The present meta-analysis enrolled altogether 9 articles. On the whole, the relationship between AGT M235T polymorphism and the cancer risk was not significant among the entire population (TT vs. MM: OR = 1.28, 95%CI = 0.80 - 2.04; TM vs. MM: OR = 0.90, 95%CI = 0.53 - 1.52; recessive model: OR = 1.13, 95%CI = 0.83 - 1.52; dominant model: OR = 0.93, 95%CI = 0.55 - 1.57). Subgroup analysis by ethnicity, cancer type, and study quality for the relationship between the AGT M235T polymorphism and cancer risk showed no significant association. According to findings in the present meta-analysis, AGT M235T polymorphism may not be related to cancer susceptibility.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The flow diagram of included/excluded studies.
Figure 2
Figure 2
Forest plot for meta-analysis of the association between the M235T polymorphism and cancer risk with TT vs. MM.
Figure 3
Figure 3
Sensitivity analysis of the association between the M235T polymorphism and cancer risk.
Figure 4
Figure 4
Begg's funnel plot analysis to detect potential publication bias for M235T polymorphism.
See this image and copyright information in PMC

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