Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov;8(6):1617-1621.
doi: 10.1016/j.euf.2022.03.005. Epub 2022 Mar 19.

Clinical Trial Protocol for ProBio: An Outcome-adaptive and Randomised Multiarm Biomarker-driven Study in Patients with Metastatic Prostate Cancer

Bram De Laere  1 , Alessio Crippa  2 , Andrea Discacciati  2 , Berit Larsson  2 , Jan Oldenburg  3 , Ashkan Mortezavi  4 , Piet Ost  5 , Martin Eklund  2 , Johan Lindberg  2 , Henrik Grönberg  6 ; ProBio Investigators
Affiliations

Clinical Trial Protocol for ProBio: An Outcome-adaptive and Randomised Multiarm Biomarker-driven Study in Patients with Metastatic Prostate Cancer

Bram De Laere et al. Eur Urol Focus. 2022 Nov.

Abstract

ProBio is an outcome-adaptive, multiarm, multiple-assignment randomised, biomarker-driven platform trial in men with metastatic castration-resistant prostate cancer. Here we describe the amended clinical protocol, focusing on expansion of the trial to include patients with de novo metastatic hormone-sensitive prostate cancer.

Trial registration: ClinicalTrials.gov NCT03903835.

Keywords: Genomics; Liquid biopsy; Outcome-adaptive; Platform trial; Precision medicine; mCRPC; mHSPC.

PubMed Disclaimer

Publication types

Associated data